CRISPR-Cas介导基因编辑技术的发展趋势及研究进展  

Development tendency and research progress of CRISPR-CAS-based Genome engineering

作　　者：杨永昌 常帅 赵欣宇 YANG Yongchang;CHANG Shuai;ZHAO Xinyu(Department of Clinical Laboratory,Seventh Medical Center of Chinese PLA General Hospital,Beijing 100010,China)

机构地区：[1]解放军总医院第七医学中心检验科,北京100010

出　　处：《现代医学与健康研究电子杂志》2022年第6期131-136,共6页Modern Medicine and Health Research

摘　　要：CRISPR-Cas系统为细菌与古生菌的一种免疫防御机制。基于该系统的基因编辑技术在基因工程领域得到广泛应用,极大地加快了该领域研究的进步。本文从CRISPR-Cas系统介导的基因组编辑技术的发展趋势和最新应用及现状进行综述。CRISPR-Cas system is used to resist exogenous viruses or plasmids in bacteria and archaea Acquired immune system of DNA invasion.The gene editing technology based on this system has brought a breakthrough revolution to the regulation and application of targeted genome modification.In this paper,we review the development and application of CRISPR-Cas system mediated genome editing technology,and provide reference for related researchers.

关 键 词：CRISPR-Cas系统 Cas9 基因组编辑技术 

分 类 号：Q78[生物学—分子生物学]