反应条件对均相沉淀法制备纳米羟基磷灰石粒径分布的影响及其表征  

Effects of Reaction Conditions on Particle Size Distribution of Nanohydroxyapatite Obtained by Homogeneous Precipitation and Characterization of its Properties

作　　者：刘文利 谢果 郑子懿 莫凯源 郑子昱 沈秀红 吴锦才 Liu Wenli;Xie Guo;Zheng Ziyi;Mo Kaiyuan;Zheng Ziyu;Shen Xiuhong;Wu Jincai(College of Material and Food,University of Electronic Science and Technology of China,Zhongshan Institute,Zhongshan 528401,China)

机构地区：[1]电子科技大学中山学院材料与食品学院,广东中山528401

出　　处：《广东化工》2022年第7期7-10,共4页Guangdong Chemical Industry

基　　金：中山市社会公益科技研究项目(2018SYF11)。

摘　　要：采用均相沉淀法在水、乙醇两种溶液体系中合成纳米羟基磷灰石(nanohydroxyapatite,nano-HAP)晶体。考察了温度、溶液体系、L-谷氨酸(Glu)等因素对样品平均粒度及粒度分布的影响。样品分别通过激光粒度仪、傅里叶变换红外光谱(Fouriertransform infrared spectroscopy,FTIR)、X射线衍射(X-ray diffraction,XRD)、透射电子显微镜(Transmission electron microscopy,TEM)、选区电子衍射(Selected area electron diffraction,SAED)、X射线能量色散仪(Energy-dispersive X-ray spectroscopy,EDX)进行表征。结果显示添加总钙量5%的Glu、室温、水溶液体系为nano-HAP最佳制备条件;在此条件下制备的样品为片状多晶体,具有较高结晶度和纯度,由Ca、P和O等元素组成,其Ca/P摩尔比为1.58。Nanohydroxyapatite powders were prepared by homogeneous precipitation method in aqueous or ethanol solution system. The effects of the main factors, including temperature, solution system, glutamic acid, on particle size and its distribution were investigated. The obtained samples were measured by laser particle size analyzer and characterized by X-ray diffraction(XRD), fourier transform infrared spectroscopy(FTIR), transmission electron microscopy(TEM)coupled with selected area electron diffraction(SAED), energy-dispersive X-ray spectroscopy(EDX). The optimum conditions for synthesis of nano-HAP were confirmed as followed: with the glutamic acid as calcium chelator(5 % of total calcium), room temperature, aqueous solution system. The 5 % Glu sample obtained under such conditions was a plate-like polycrystal with high crystallinity and purity, which was predominantly composed of elements including calcium(Ca),phosphorous(P), oxygen(O), etc. The calcium/phosphorous(Ca/P) ratio of 5 % Glu sample was equal to 1.58.

关 键 词：纳米羟基磷灰石 均相沉淀法 反应条件 粒径分布 表征 

分 类 号：R318.08[医药卫生—生物医学工程]