猪繁殖与呼吸障碍综合征病毒NSP4蛋白研究进展  

NSP4 protein in porcine reproductive and respiratory disorders syndrome: research progress

作　　者：彭静怡 冯健男 刘广超 乔春霞 柴立辉 PENG Jing-yi;FENG Jian-nan;LIU Guang-chao;QIAO Chun-xia;CHAI Li-hui(Key Laboratory of Cellular and Molecular Immunology,Joint National Laboratory for Antibody Drug Engineering,Henan University School of Medicine,Kaifeng,Henan 475004,China;State Key Laboratory of Toxicology and Medical Countermeasures,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]河南大学基础医学院,抗体药物开发技术国家地方联合工程实验室,河南省细胞与分子免疫学重点实验室,河南开封475004 [2]军事科学院军事医学研究院毒物药物研究所,抗毒药物与毒理学国家重点实验室,北京100850

出　　处：《军事医学》2022年第1期64-69,共6页Military Medical Sciences

基　　金：国家科技重大专项(2018ZX09J18107004)。

摘　　要：猪繁殖与呼吸障碍综合征病毒(PRRSV)能够引起猪繁殖与呼吸障碍综合征,已成为全球影响生猪养殖业发展的重要传染性病毒之一。NSP4蛋白是PRRSV的3C样丝氨酸蛋白酶。在病毒增殖过程中,NSP4蛋白对病毒蛋白的表达与加工起核心作用,负责多聚蛋白的切割。该蛋白在病毒生命周期中的关键作用使其成为理想的抗病毒靶点候选者。该文综述了NSP4的结构、功能、作用机制及在防治PRRS中的作用研究进展。The porcine reproductive and respiratory syndrome virus(PRRSV),which can cause the porcine reproductive and respiratory syndrome,has become one of the most important infectious viruses affecting the development of the swine farming industry worldwide. NSP4 is a 3C-like serine protease of PRRSV. During viral proliferation,NSP4 plays a central role in the expression and modification of viral proteins and is responsible for the cleavage of polyproteins. The critical role of this protein in the viral life cycle makes it an ideal target candidate against the virus. In this review,we summarize the structure,function,and mechanism of NSP4 as well as the reserch progress in combating PRRS diseases.

关 键 词：猪繁殖和呼吸综合征 病毒非结构蛋白质类 致病机制 抗体 防治 

分 类 号：S855.3[农业科学—临床兽医学]