不同插入途径的3种肽研究进展  

Three peptides with different insertion pathways: research progress

作　　者：胡林晗 孙莹 杨鹏 石艳春[1] 陈国江 HU Lin-han;SUN Ying;YANG Peng;SHI Yan-chun;CHEN Guo-jiang(Inner Mongolia Key Laboratory of Molecular Biology,Inner Mongolia Medical University,Hohhot 010058,China;Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]内蒙古医科大学内蒙古自治区分子生物学重点实验室,呼和浩特010058 [2]军事科学院军事医学研究院毒物药物研究所,北京100850

出　　处：《军事医学》2022年第1期74-77,共4页Military Medical Sciences

基　　金：国家自然科学基金(81672803,81871252,81660272)。

摘　　要：某些具有特殊结构的肽由于其高效的组织靶向性和低毒性,以及对靶蛋白具有较高的特异性和亲和力,适合用于疾病的诊断和靶向治疗。该文就细胞穿透肽、低pH插入肽和尾锚定蛋白的结构、靶向机制和应用的研究进展进行了综述。Some peptides with unique structures can be used for disease diagnosis and targeted therapy because of their high tissue targeting and low toxicity,as well as high specificity and affinity for target proteins. This review summarizes three types of peptides,namely cell penetrating peptide(CPP),pH low insertion peptide(pHLIP),tail-anchored protein(TA),and describes their structure,targeting mechanisms and applications.

关 键 词：肽类 细胞穿透肽 低pH插入肽 尾锚定蛋白 

分 类 号：R977.6[医药卫生—药品]