免疫相关营养素对新生儿坏死性小肠结肠炎预防作用的研究进展  

Research advances in protective effects of immunonutrients on necrotizing enterocolitis

作　　者：曹旭清 朱海涛[1] 沈淳[1] Cao Xuqing;Zhu Haitao;Shen Chun(Department of Pediatric Surgery,Children's Hospital of Fudan University,National Children's Medical Center,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心,复旦大学附属儿科医院外科,上海201102

出　　处：《中华小儿外科杂志》2022年第3期278-282,共5页Chinese Journal of Pediatric Surgery

基　　金：国家自然科学基金(81873849);上海市自然科学基金(18ZR1405200)。

摘　　要：坏死性小肠结肠炎(necrotizing enterocolitis,NEC)是新生儿期的危重肠道疾病之一,常见于早产儿。虽然早产儿护理及治疗结局不断提升,NEC的手术率仍较高,病死率可高达40%左右,是威胁早产儿生命和生存质量的疾病之一。免疫相关营养素作为一类特殊的具有免疫功能的营养素,近年来在预防和减轻NEC疾病严重程度方面展现出较大的应用前景,本文就人乳低聚糖、乳铁蛋白、外泌体、益生菌、益生元以及合生元对防治NEC的研究进展做一综述。As one of severe intestinal diseases during neonatal period,necrotizing enterocolitis(NEC)endangers the survival and quality-of-life of preterm infants.Despite continuous improvements of care and outcomes,surgical rate of NEC has remained high.NEC-related mortality may be as high as 40%.Immunonutrients are special kinds of nutrients affecting the function of immune system.Recently several immunonutrients have demonstrated great potentials of lowering the risk and severity of NEC.This review summarized the protective roles of human milk oligosaccharides(HMOs),lactoferrin,exosomes,probiotics,prebiotics and synbiotics.

关 键 词：小肠结肠炎 坏死性 免疫营养素 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]