基于数据挖掘的抗流感病毒中药用药规律研究  

Study on the medication rule of Chinese medicine against influenza virus based on data mining

作　　者：鲁玉强 付琳 郝玉麒 丁辉[2] 石曌玲 李如英 张国成 LU Yuqiang;FU Lin;HAO Yuqi;DING Hui;SHI Zhaoling;LI Ruying;ZHANG Guocheng(Shaanxi University of Chinese Medicine,Xianyang 712046, China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学第二附属医院,陕西咸阳712046

出　　处：《中国中西医结合儿科学》2022年第2期101-106,共6页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：陕西中医药大学第二附属医院学科创新团队建设项目(2020XKTD-A02)。

摘　　要：目的 整理总结核心期刊等高质量期刊中关于抗流感病毒中药的用药规律,为预防和治疗流行性感冒等疾病提供中药指导。方法 以“中药”“流感病毒”“流行性感冒”为主题词,检索CNKI、VIP、WanFang等数据库,筛选核心期刊中的相关文献并整理其选方用药。运用Excel 2010、古今医案云平台、SPSS Modeler 18.0、SPSS 22.0等软件对收集到的数据进行统计分析。结果 检索到核心期刊1131篇,筛选出符合纳排标准的文献135篇,共计109个中药组方,170味中药,出现总频次为1655次。出现频次最多的3味药为甘草、金银花、连翘;药物功效前三类主要分为清热解毒、疏风散热、清热泻火;药物药性多寒、温、平;药味多为苦、甘、辛;十二归经上多属肺、胃、心、脾、肝经;关联规则得到20个配伍药对,荆芥-连翘、荆芥-金银花、牛蒡子-金银花等;聚类分析得到4个新方。结论 抗流感病毒中药用药具有一定规律性,为防治流行性感冒提供了重要的参考价值。Objective To summarize the rules in the use of traditional Chinese medicine(TCM)against influenza virus in core journals and other high-quality journals,and to provide TCM guidance for the prevention and treatment of influenza and other diseases.Methods With"Chinese medicine","influenza virus"and"influenza"as subject words,CNKI,VIP,and Wanfang databases were searched,relevant literatures in core journals were screened and the prescription drugs were sorted out.Excel 2010,ancient and modern medical case cloud platform,SPSS Modeler 18.0,and SPSS Statistics 22.0 were used for statistical analysis of the collected data.Results Totally 1131 articles from core journals were retrieved and 135 articles meeting the inclusion criteria were screened out,including 109 TCM prescriptions and 170 TCM ingredients,with a total frequency of 1655 times.The three herbs most frequently used were licorice,honeysuckle and forsythia.The first three types of drug efficacy were heat-clearing and detoxification,wind-clearing and heat-dissipating,heat-clearing and fire-reducing.The medicinal properties were mostly cold,warm and flat.The medicinal flavor was mostly bitter,sweet and spicy.Of the twelve meridians most drugs belonged to the lung,stomach,heart,spleen and liver meridians.According to association rules,20 compatible drug pairs were obtained,including schizonepeta-forsythia,schizonepeta-honeysuckle,and arctiumlappa-honeysuckle.Four new prescriptions were obtained by cluster analysis.Conclusion The use of traditional Chinese medicine against influenza virus has a certain regularity,which provides an important reference value for the prevention and treatment of influenza.

关 键 词：流行性感冒 中药 用药规律 数据挖掘 

分 类 号：R725.6[医药卫生—儿科]