膝关节骨性关节炎关节腔内注射富血小板血浆与臭氧+玻璃酸钠的临床对比研究  

Clinical effect comparative of intra-articular injection of platelet-rich plasma and ozone+sodium hyaluronate in knee osteoarthritis

作　　者：张燕[1] 马民玉[1] Zhang Yan;Ma Minyu(Department of Pain Management,Anesthesiology and Perioperative Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院麻醉与围术期医学部疼痛科,郑州450052

出　　处：《河南外科学杂志》2022年第2期11-13,共3页Henan Journal of Surgery

基　　金：河南省医学科技攻关计划项目(20160205)。

摘　　要：目的探讨膝关节骨性关节炎(KOA)关节腔内注射富血小板血浆(PRP)与臭氧+玻璃酸钠的临床疗效。方法前瞻性纳入2020-05—2021-04于郑州大学第一附属医院麻醉与围术期医学部疼痛科行关节腔内注射治疗的60例KOA患者,根据用药方案分为PRP组和臭氧+玻璃酸钠组(对照组)。比较2组患者的基线资料,记录治疗前和治疗后1周、4周、12周、24周的视觉模拟评分(VAS)、骨关节炎程度WOMAC评分和膝关节功能恢复效果IKDC评分。统计治疗后的不良反应和并发症。结果共纳入60例患者,每组30例。2组患者的基线资料差异无统计学意义(P>0.05)。治疗后1周、4周、12周、24周时2组患者的VAS评分、WOMAC评分均低于治疗前,IKDC评分高于治疗前,差异均有统计学意义(P<0.05)。治疗前,治疗后1周、4周、12周时2组患者间的VAS评分、WOMAC评分、IKDC评分差异无统计学意义(P>0.05)。治疗后24周PRP组患者的VAS评分、WOMAC评分均低于对照组,IKDC评分高于对照组,差异均有统计学意义(P<0.05)。2组患者均未发生严重不良反应及并发症,差异无统计学意义(P>0.05)。结论对KOA患者实施关节腔内注射PRP与臭氧+玻璃酸钠的近期疗效相仿,其中注射PRP的长期效果更佳。但仍需大样本量的前瞻性随机对照研究予以证实。Objective To investigate the clinical efficacy of intra-articular injection of platelet-rich plasma(PRP)and ozone+sodium hyaluronate in knee osteoarthritis(KOA).Methods A total of 60 patients with KOA who underwent intra-articular injection were prospectively enrolled.These patients are from Department of Anesthesia and Perioperative Medicine,The First Affiliated Hospital of Zhengzhou University from May 2020 to April 2021.According to the different medication regimen,patients were divided into PRP group and ozone+sodium hyaluronate group(control group).The baseline data of the patients in the two groups were compared,and the visual analogue scale(VAS),the WOMAC score of the degree of osteoarthritis and the IKDC score of the knee joint function recovery effect were recorded before treatment and at 1 week,4 weeks,12 weeks and 24 weeks after treatment.Adverse reactions and complications after treatment were recorded.Results A total of 60 patients were included,30 in each group.There was no significant difference in baseline data between the two groups(P>0.05).At 1 week,4 weeks,12 weeks,and 24 weeks after treatment,the VAS scores and WOMAC scores of the two groups were lower than those before treatment,and the IKDC scores were significantly higher than those before treatment,and the differences were statistically significant(P<0.05).There was no significant difference in VAS score,WOMAC score and IKDC score between the two groups before treatment,1 week,4 weeks and 12 weeks after treatment(P>0.05).At 24 weeks after treatment,the VAS score and WOMAC score of the PRP group were lower than those of the control group,and the IKDC score was higher than that of the control group.The differences were statistically significant(P<0.05).There were no serious adverse events and complications in the two groups,and the difference was not statistically significant(P>0.05).Conclusion The short-term effect of intra-articular injection of PRP in KOA patients is similar to that of ozone+sodium hyaluronate,and the long-term effect of

关 键 词：富血小板血浆 膝关节骨性关节炎 臭氧 玻璃酸钠 

分 类 号：R684.3[医药卫生—骨科学]