去氢枞酸菲环结构改性及衍生物活性研究进展  

Advances in Structural Modification of Dehydroabietic Phenanthrene Ring and Activity of Derivatives

作　　者：韦有杰 马璐 莫秀庆 雷禄 Wei Youjie;Ma Lu;Mo Xiuqing;Lei Lu(College of Preparatory Education,Baise University Baise 533000,China)

机构地区：[1]百色学院预科教育学院,广西百色533000

出　　处：《云南化工》2022年第4期1-5,共5页Yunnan Chemical Technology

基　　金：广西教育厅2020年度广西高校中青年教师科研基础能力提升项目(2020KY19016)。

摘　　要：去氢枞酸是歧化松香的主要成分之一,是一种结构中含有羧基、菲环骨架等手性中心的二萜类天然化合物。对去氢枞酸的改性多集中于羧基,但随着研究的深入,结构中菲环骨架的改性也逐渐增多。改性化合物表现出和羧基改性衍生物相似的如抗癌等的生物活性,有的还具有羧基改性化合物所没有的光学活性。主要从去氢枞酸菲环结构的改性及其衍生物活性两方面,综述了近五年来所取得的研究成果,并对下一步研究进行了展望。Dehydroabietic acid is one of the main components of disproportionated rosin,which is a kind of natural diterpenoids containing chiral centers such as carboxyl group and phenanthrene skeleton.The modification of dehydroabietic acid mainly focused on carboxylic group,but with the deepening of research,the modification of phenanthrene ring skeleton in the structure also increased gradually.The modified compounds also exhibit similar biological activities as carboxylic derivatives,such as anticancer activities,and some have optical activities that carboxylic derivatives do not.In this paper,the modification of phenanthrene dehydroabietic acid structure and the activity of its derivatives are reviewed,and the future research is prospected.

关 键 词：去氢枞酸 菲环结构 衍生物 活性 

分 类 号：O624[理学—有机化学]