Cu(Ⅱ)联咪唑硝基衍生物配合物的合成表征及其与CT-DNA相互作用研究  

Synthesis,Characterization and Interaction with CT-DNAof Cu(Ⅱ)Complex based on Nitrobiimidazole Derivative

作　　者：王航天 范倩倩 李焱 杨莉宁[1] Wang Hangtian;Fan Qianqian;Li Yan;Yang Lining(Department of Pharmacy,Medical University of Xi'an,Xi'an 710021,China)

机构地区：[1]西安医学院药学院,陕西西安710021

出　　处：《云南化工》2022年第4期30-32,共3页Yunnan Chemical Technology

基　　金：陕西省大学生创新创业训练项目(S202011840060);西安医学院校级大学生创新创业训练项目(121520060)。

摘　　要：以联咪唑硝基衍生物(NO_(2)Me_(2)biim)为配体,通过直接法合成了其铜(Ⅱ)配合物。利用元素分析、红外光谱、紫外-可见光谱、摩尔电导率等方法对配合物的组成和结构进行了表征。以电子光谱、荧光光谱和黏度法研究了配体NO_(2)Me_(2)biim及配合物与小牛胸腺DNA(CT-DNA)的相互作用机制。研究表明,配体NO_(2)Me_(2)biim和配合物与CT-DNA分别以典型插入和部分插入模式进行相互作用。The copper complex was synthesized by taking nitrobiimidazole derivative(NO_(2)Me_(2)biim)as ligand,its structure and composition was characterized by Uv-vis spectral,molar conductivity,IR spectroscopy,and elemental analysis.The binding property of the ligand and complex toward calf thymus DNA(CT-DNA)was figured out via electronic absorption,fluorescence spectra and viscosity measurements.Results showed that ligand and the complex combined with DNA by partial insertion and insertion mode,respectively.

关 键 词：联咪唑硝基衍生物 Cu(Ⅱ)配合物 与DNA相互作用 

分 类 号：O614[理学—无机化学]