2010-2019年宝鸡市 手足口病流行特征及时空聚集分析  

The epidemiological characteristics and spatial-temporal clustering of hand-foot-mouth disease in Baoji,from 2010 to 2019

作　　者：何微[1] 邓峰[1] 田辉[1] 胡晓倩[1] 付海龙[1] 贾敏[1] HE Wei;DENG Feng;TIAN Hui;HU Xiao-qian;FU Hai-long;JIA Min(Department of Infectious Disease Prevention and Control,Baoji Center for Disease Control and Prevention,721006,China)

机构地区：[1]宝鸡市疾病预防控制中心传染病防制科,721006

出　　处：《传染病信息》2022年第2期151-156,共6页Infectious Disease Information

基　　金：陕西省卫生健康科研基金项目(2018D010)。

摘　　要：目的 分析陕西省宝鸡市2010—2019年手足口病流行特征及时空聚集性,为本市的手足口病防控提供理论依据。方法 收集宝鸡市2010—2019年手足口病发病数据和病原学监测结果,建立数据库,分析手足口病流行特征及优势病原谱的变化,再应用ArcGIS 10.1系统对手足口病发病进行空间自相关及热点分析。结果 2010—2019年宝鸡市累计报告手足口病35546例,平均发病率为94.62/10万,男性发病率高于女性(χ^(2)=1031.484,P=0.000);各年龄组发病率不同(χ^(2)_(趋势)=61405.833,P=0.000),其中1~2岁组年平均发病率最高(2572.65/10万)。宝鸡市手足口病病原谱的构成:2010年优势病原为Cox A16(65.14%),2011年、2012年和2014年优势病原为EV-A71(82.67%、48.97%和54.87%),2013年、2015—2018年均以其他肠道病毒为主(62.11%、49.34%、53.02%、42.29%、80.50%),2019年Cox A16和其他肠道病毒比例相当(55.42%vs.43.07%),各年间优势病原分布不同(χ^(2)=874.879,P=0.000)。全局自相关分析发现2014年、2017年、2018年、2019年具有空间聚集性,高值聚集区为本市南部地区及主城区。结论 陕西省宝鸡市手足口病发病存在时空聚集性,应加强重点地区疫情防控,制定针对性防控措施。Objective To provide theoretical basis for prevention and control of hand-foot-mouth disease(HFMD)via analyzing the epidemiological characteristics and spatial-temporal clustering statistic of HFMD in Baoji,Shaanxi,from 2010 to 2019.Methods The incidence andetiological surveillance data of HFMD from 2010 to 2019 in Baoji were collected to establish database to analyze the epidemiological characteristics and the changes of dominant pathogenic spectrum.ArcGIS 10.1 software was applied to perform the spatial autocorrelation and clustering areas analysis of HFMD incidence.Results A total of 35546 cases of HFMD were reported cumulatively in Baoji City from 2010 to 2019,with an average annual incidence of 94.62/100000.The incidence of male was higher than that of female(χ^(2)=1031.484,P=0.000).The incidence vary among age groups(χ^(2)=61405.833,P=0.000),and 1 to 2-year-olds presented the highest mean annual incidence as 2572.65/100000.There were significant differences in dominant pathogen spectrum among different years(χ^(2)=874.879,P=0.000),it was Cox A16 in 2010(65.14%),and EV-A71 in 2011(82.67%),2012(48.97%)and 2014(54.87%).In 2013、2015 to 2018,the dominant pathogens were other enteroviruses(62.11%、49.34%、53.02%、42.29%and 80.50%respectively).The proportions of Cox A16 and other enteroviruses were comparative(55.42%vs.43.07%)in 2019.The global autocorrelation analysis demonstrated a significant spatial correlation in 2014、2017、2018、2019,clustering areas were mainly distributed southern and urban areas.Conclusions The incidence of HFMD had an obvious spatiotemporal distribution in Baoji.The epidemic prevention and control in key areas should be strengthened,and targeted prevention and control measures should be developed.

关 键 词：手足口病 流行病学特征 时空聚集 肠道病毒 COXA16 EV-A71 

分 类 号：R512.57[医药卫生—内科学] R195.4[医药卫生—临床医学]