六安市1~12岁儿童水痘-带状疱疹病毒抗体水平调查  

Seroepidemiology of varicella-zoster virus antibody levels among children aged 1 to 12 years in Lu'an City

作　　者：陈蓓蕾 王瑶 陈智超[1] 潘璠 解少煜 秦伟[2,3] CHEN Beilei;WANG Yao;CHEN Zhichao;PAN Fan;XIE Shaoyu;QIN Wei(Lu'an Center for Disease Control and Prevention,Lu'an,Anhui 237000,China;Anhui Medical University,Hefei,Anhui 230032,China)

机构地区：[1]六安市疾病预防控制中心微生物检验科,安徽六安237000 [2]六安市疾病预防控制中心,安徽六安237000 [3]安徽医科大学,安徽合肥230032

出　　处：《预防医学》2022年第5期503-506,共4页CHINA PREVENTIVE MEDICINE JOURNAL

摘　　要：目的了解安徽省六安市儿童水痘-带状疱疹病毒(VZV)抗体水平,为完善水痘免疫策略提供依据。方法于2018年7月—2019年2月,采用分层随机抽样方法抽取六安市1~12岁儿童为调查对象,通过问卷调查收集人口学信息,通过安徽省免疫规划信息管理平台或查阅预防接种证收集儿童水痘疫苗接种情况;采用酶联免疫吸附试验检测血清VZV-IgG抗体,计算抗体阳性率和几何平均浓度(GMC);分析接种水痘疫苗后不同时间间隔VZV-IgG抗体水平变化。结果调查734人,年龄为(6.94±2.95)岁。男童412人,占56.13%;女童322人,占43.87%。有水痘疫苗接种史514人,占70.03%;接种1剂次501人,占68.26%;接种2剂次13人,占1.77%。检测VZV-IgG抗体阳性297人,阳性率为40.46%;GMC为74.97(95%CI:65.55~85.75)mIU/mL。未接种、接种1剂次和接种2剂次儿童VZV-IgG抗体阳性率分别为34.55%、42.91%和46.15%,GMC分别为53.04、86.31和114.86 mIU/mL。接种最后1剂水痘疫苗与血标本采集时间间隔为(5.21±2.79)年。接种后第4年VZV-IgG抗体阳性率和GMC均下降至最低水平,分别为31.48%和49.96 mIU/mL。结论六安市1~12岁儿童VZV-IgG抗体水平较低,抗体阳性率受年龄和接种剂次影响。推荐2剂次免疫策略。Objective To detect varicella-zoster virus(VZV)antibody levels among children aged 1 to 12 years in Lu'an City,Anhui Province,so as to provide insights into perfection of the varicella immunization strategy.Methods Children aged 1 to 12 years were recruited from Lu'an City using the stratified random sampling method from July 2018 to February 2019,and subjects'demographics were collected using questionnaires.The inoculation of varicella vac⁃cines was retrieved through the Anhui Immunization Information Management System or review of preventive immuniza⁃tion certificates,and the serum VZV IgG antibody was detected using enzyme-linked immunosorbent assay(ELISA).The seroprevalence and geometric mean concentration of the VZV-IgG antibody were estimated,and the changes of se⁃rum the VZV-IgG antibody levels were analyzed at different time intervals following varicella vaccination.Results To⁃tally 734 children were surveyed,with a mean age of(6.94±2.95)years,and the subjects included 412 boys(56.13%)and 322 girls(43.87%).There were 514 children(70.03%)with a history of varicella vaccination,including 501 children(68.26%)with one dose of varicella vaccine and 13 children(1.77%)with two doses.There were 297 children(40.46%)positive for VZV-IgG antibody,with seroprevalence of 40.46%,and the GMC of VZV-IgG antibody was 74.97(95%CI:65.55-85.75)mIU/mL.The seroprevalence of the VZV-IgG antibody were 34.55%,42.91%,and 46.15%among the unvaccinated children and children receiving one dose and two doses of varicella vaccine,with the GMCs of 53.04,86.31 and 114.46 mIU/mL,respectively.The mean time interval between inoculation of the last dose of varicella vaccine and blood sample collection was(5.21±2.79)years,and the lowest seroprevalene(31.48%)and GMC of the VZV-IgG antibody(49.96 mIU/mL)were found 4 years after inoculation of varicella vaccine.Conclusions The serum VZV-IgG antibody level is low among children aged 1 to 12 years in Lu'an City,and the seroprevalence of the VZV-IgG antibody is affected by age and doses of

关 键 词：水痘 水痘-带状疱疹病毒 抗体 血清流行病学 

分 类 号：R511.5[医药卫生—内科学]