附子多糖研究进展  

Research Progress of Aconite Polysaccharide

作　　者：汝沈圆 高静东[1] Ru Shenyuan;Gao Jingdong(Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215000,China)

机构地区：[1]南京中医药大学附属苏州市中医医院,江苏苏州215000

出　　处：《亚太传统医药》2022年第4期235-239,共5页Asia-Pacific Traditional Medicine

基　　金：姑苏卫生人才培养项目(GSWS2020081)。

摘　　要：附子作为一味传统中药在我国有悠久的用药历史,目前对附子的研究主要集中在生物碱领域,但随着植物多糖抗肿瘤、抗氧化、调节免疫等多种生物活性的发现,对附子多糖的研究逐渐增加。通过参考现有文献,对附子多糖当前研究进展进行综述,主要包括附子多糖的结构、提取、纯化和抗肿瘤、促进免疫应答的激活、抑制血管钙化、改善胰岛素抵抗及抗抑郁等药理作用,重点对其抗肿瘤、调节免疫机制进行分析并提出新的思考。As a traditional Chinese medicine,Aconiti Lateralis Radix Praeparata has been used for a long time in China.Modern research on Aconite is mainly in the field of alkaloids.However,with the multiple biological activities of plant polysaccharides discovered,such as anti-tumor,anti-oxidation and regulating immunity,studies about Aconite polysaccharides has increased.This article reviews the current research progress of Aconite polysaccharides,including the structure,extraction,purification and pharmacological actions like anti-tumor,promotion of immune response activation,inhibition of vascular calcification,improvement of insulin resistance and antidepressant with reference to extant literature.It is focused on the analysis of mechanisms in anti-tumor and immune regulation and also new thoughts.

关 键 词：附子多糖 分子结构 提取 分离纯化 药理作用 

分 类 号：R282[医药卫生—中药学]