COX-2、SFRP4和WBP2在子宫腺肌病病灶中的表达及与临床特征的关系  

Expressions of COX-2,SFRP4 and WBP2 in Adenomyosis and Their Correlations with Clinical Features

作　　者：石路莹 段静雅 张继花 李灿宇[1] SHI Luying;DUAN Jingya;ZHANG Jihua;LI Canyu(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;不详)

机构地区：[1]郑州大学第三附属医院,河南郑州450052

出　　处：《中国医学创新》2022年第13期1-7,共7页Medical Innovation of China

基　　金：2018年度河南省医学科技攻关计划联合共建项目(2018020167)。

摘　　要：目的:探究环氧化酶-2(cyclooxygenase-2,COX-2)、分泌型卷曲相关蛋白4(secreted frizzled-related protein 4,SFRP4)和WW域结合蛋白2(WW-domain binding protein 2,WBP2)在子宫腺肌病中的表达及其与子宫腺肌病临床特征的关系。方法:选取2019年1月-2020年6月在郑州大学第三附属医院确诊子宫腺肌病并进行手术切除子宫的患者40例,收集40例患者的异位内膜标本,统计患者的痛经、月经量及子宫大小等临床资料。采用免疫组化SP法分别检测COX-2、SFRP4和WBP2在子宫腺肌病异位病灶中的表达,分析其相互关系及其与子宫腺肌病临床特征的关系。结果:COX-2和SFRP4的表达呈正相关(r_(s)=0.533,P<0.01),COX-2和WBP2的表达呈正相关(r_(s)=0.544,P<0.01),WBP2和SFRP4的表达呈正相关(r_(s)=0.574,P<0.01)。无或轻度痛经及中度痛经组与重度痛经组COX-2和SFRP4低表达与高表达分布情况比较,差异均有统计学意义(P<0.05),而两组WBP2低表达与高表达分布情况比较,差异无统计学意义(P>0.05)。子宫体积正常组与子宫体积增大组COX-2、SFRP4及WBP2低表达与高表达分布情况比较,差异均无统计学意义(P>0.05)。月经量正常组与月经量增大组COX-2、SFRP4及WBP2低表达与高表达分布情况比较,差异均无统计学意义(P>0.05)。结论:COX-2、SFRP4和WBP2可能参与了子宫腺肌病的发生发展,COX-2可作为治疗子宫腺肌病潜在的分子靶点。Objective:To explore the expressions of cyclooxygenase-2(COX-2),secreted frizzled-related protein 4(SFRP4)and WW-domain binding protein 2(WBP2)in adenomyosis and their correlations with the clinical features of adenomyosis.Method:A total of 40 patients who were diagnosed with adenomyosis by pathology and underwent hysterectomy in the Third Affiliated Hospital of Zhengzhou University from January 2019 to June 2020 were selected.The ectopic endometrium specimens of the 40 patients were collected,and the clinical data of dysmenorrhea,menstrual volume and uterine size were collected.The expressions of COX-2,SFRP4 and WBP2 in ectopic lesions of adenomyosis were detected by immunohistochemical SP method.The relationships between COX-2,SFRP4 and WBP2 and their relationships with the clinical characteristics of adenomyosis were analyzed.Result:The expression of COX-2 and SFRP4 was positively correlated(r_(s)=0.533,P<0.01),the expression of COX-2 and WBP2 was positively correlated(r_(s)=0.544,P<0.01),and the expression of WBP2 and SFRP4 was positively correlated(r_(s)=0.574,P<0.01).There were significant differences in the distributions of low expression and high expression of COX-2 and SFRP4 between no or mild dysmenorrhea and moderate dysmenorrhea group and severe dysmenorrhea group(P<0.05),but there was no significant difference in the distribution of low expression and high expression of WBP2 between the two groups(P>0.05).There were no significant differences in the distributions of low expression and high expression of COX-2,SFRP4 and WBP2 between normal uterine volume group and increased uterine volume group(P>0.05).There were no significant differences in the distributions of low expression and high expression of COX-2,SFRP4 and WBP2 between normal menstrual volume group and increased menstrual volume group(P>0.05).Conclusion:COX-2,SFRP4 and WBP2 may be involved in the occurrence and development of adenomyosis,COX-2 can be used as a potential target for the treatment of adenomyosis.

关 键 词：子宫腺肌病 COX-2 SFRP4 WBP2 免疫组化 痛经 

分 类 号：R711.71[医药卫生—妇产科学]