左氧氟沙星联合甲硝唑对妇科患者腹腔镜术后预防切口感染的效果研究  

Effect of levofloxacin combined with metronidazole on prevention of incision infection after laparoscopic surgery in gynecological patients

作　　者：阳艳 Yang Yan(Department of Infection Management,Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou 510800,China)

机构地区：[1]广州市中西医结合医院感染管理科,广东广州510800

出　　处：《实用妇科内分泌电子杂志》2022年第4期106-109,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析左氧氟沙星联合甲硝唑对妇科患者腹腔镜术后预防切口感染的临床效果。方法选取98例行妇科腹腔镜手术患者,按照随机数字表法分为对照组与试验组,每组49例。对照组采用甲硝唑治疗,试验组采用甲硝唑联合左氧氟沙星治疗。比较两组手术前后炎性因子水平及术后感染率。结果手术前,两组血清可溶性粘附分子-1、C反应蛋白、白细胞介素-6水平比较,差异无统计学意义(P>0.05);手术后3d,两组血清可溶性粘附分子-1、C反应蛋白、白细胞介素-6水平均明显低于手术前,且试验组明显低于对照组,差异有统计学意义(P<0.05)。试验组术后感染率为4.08%,明显低于对照组的16.33%,差异有统计学意义(P<0.05)。结论左氧氟沙星联合甲硝唑在预防妇科患者腹腔镜术后切口感染效果显著,且可明显降低炎性因子水平,值得临床推广与应用。Objective To analyze the clinical effect of levofloxacin combined with metronidazole on prevention of incision infection in gynecological patients after laparoscopic surgery.Methods 98 patients undergoing gynecological laparoscopic surgery were selected and divided into control group and experimental group according to random number table method,with 49 cases in each group.The control group was treated with metronidazole,and the experimental group was treated with metronidazole combined with levofloxacin.The levels of inflammatory factors and postoperative infection rates were compared between the two groups before and after operation.Results Before surgery,there was no significant difference in serum soluble adhesion molecule-1,C-reactive protein and interleukin-6 levels between the two groups(P>0.05).On day 3 after operation,the levels of soluble adhesion molecule-1,C-reactive protein and interleukin-6 in serum of 2 groups were significantly lower than before operation,and those in experimental group were significantly lower than those in control group,the difference was statistically significant(P<0.05).The postoperative infection rate of experimental group was 4.08%,which was significantly lower than that of control group(16.33%),and the difference was statistically significant(P<0.05).Conclusion Levofloxacin combined with metronidazole has a significant effect on preventing incision infection after laparoscopic surgery in gynecological patients,and can significantly reduce the level of inflammatory factors,which is worthy of clinical promotion and application.

关 键 词：妇科 腹腔镜术 左氧氟沙星 甲硝唑 切口感染 

分 类 号：R713[医药卫生—妇产科学]