三维彩色血管能量成像联合鳞状上皮细胞癌相关抗原、癌胚抗原对Ⅰ~Ⅱ期宫颈癌的诊断效能  

Diagnosis Efficacy of Three-Dimensional Color Power Angiography Combined with Squamous Cell Carcinoma Associated Antigen and Carcinoembryonic Antigen in StageⅠ-ⅡCervical Cancer

作　　者：于芳 陈纪昀[2] 高子涵 YU Fang;CHEN Jiyun;GAO Zihan(Department of Ultrasound,Yongmei General Hospital,Shangqiu 476600,China;Department of Ultrasound,Henan Provincial People’s Hospital,Zhengzhou 450000,China;Department of Ultrasound,the Third People’s Hospital of Shangqiu,Shangqiu 476000,China)

机构地区：[1]永城市永煤总医院超声科,河南商丘476600 [2]河南省人民医院超声科,河南郑州450000 [3]商丘市第三人民医院超声科,河南商丘476000

出　　处：《河南医学研究》2022年第9期1654-1657,共4页Henan Medical Research

摘　　要：目的探讨三维彩色血管能量成像(3 D-CPA)联合鳞状上皮细胞癌相关抗原(SCC-Ag)、癌胚抗原(CEA)提高Ⅰ~Ⅱ期宫颈癌诊断效能的临床研究。方法选取2019年4月至2021年4月河南省人民医院收治的119例宫颈癌患者,根据国际妇产科联盟(FIGO)分期分为Ⅰ期组(53例)和Ⅱ期组(66例),纳入同期体检健康人群50例为对照组。观察比较3组3 D-CPA检查结果及SCC-Ag、CEA水平以及不同分期患者3 D-CPA、SCC-Ag、CEA的检测阳性率。结果3组3 D-CPA血管化指数(VI)、血流指数(FI)比较,差异有统计学意义(P<0.05);宫颈癌患者VI、FI低于对照组,Ⅱ期组VI、FI、钙化直径大于Ⅰ期组(P<0.05)。3组SCC-Ag、CEA水平比较,差异有统计学意义(P<0.05);宫颈癌患者SCC-Ag、CEA水平高于对照组,且Ⅱ期高于Ⅰ期(P<0.05)。Ⅱ期患者3 D-CPA、SCC-Ag、CEA检测阳性率高于Ⅰ期患者(P<0.05)。受试者工作特征曲线分析,3 D-CPA、SCC-Ag、CEA及联合检测的曲线下面积分别为0.669、0.637、0.535、0.841,联合检测具有一定的诊断价值,其敏感度为90.9%,特异度为77.4%。结论3 D-CPA、SCC-Ag、CEA联合检测可有效提高Ⅰ~Ⅱ期宫颈癌的诊断效能,具有一定的临床诊断价值。Objective To investigate the clinical study of three-dimensional color power angiography(3 D-CPA)combined with squamous cell carcinoma associated antigen(SCC-Ag)and carcinoembryonic antigen(CEA)in improving the diagnostic efficacy of stageⅠ-Ⅱcervical cancer.Methods A total of 119 patients with cervical cancer admitted to Henan Provincial People’s Hospital from April 2019 to April 2021 were selected and divided into stageⅠgroup(53 cases)and stageⅡgroup(66 cases)according to International Federation of Gynecology and Obstetrics(FIGO)stage,and 50 healthy people during the same period were included as control group.The results of 3D-CPA,SCC-Ag and CEA levels,and the positive rates of 3D-CPA,SCC-Ag and CEA in different stages were observed and compared among three groups.Results There were statistical differences in vascularization index(VI)and flow index(FI)among three groups(P<0.05).VI and FI in patients with cervical cancer were lower than those in control group,and VI,FI and calcification diameter in stageⅡgroup were larger than those in stageⅠgroup(P<0.05).There were statistical differences in SCC-Ag and CEA levels among three groups(P<0.05).SCC-Ag and CEA levels in patients with cervical cancer were higher than those in control group,and those in stageⅡpatients were higher than those in stageⅠpatients(P<0.05).The positive rates of 3D-CPA,SCC-Ag and CEA in stageⅡpatients were higher than those in stageⅠpatients(P<0.05).Receiver operating characteristic curve analysis showed that area under the curve of 3D-CPA,SCC-Ag,CEA and combined detection were 0.669,0.637,0.535 and 0.841,respectively,and combined detection had certain detection value,with a sensitivity of 90.9%and a specificity of 77.4%.Conclusion The combined detection of 3D-CPA,SCC-Ag and CEA can effectively improve the diagnosis of stageⅠ-Ⅱcervical cancer and has certain clinical diagnostic value.

关 键 词：宫颈癌 三维彩色血管能量成像 鳞状上皮细胞癌相关抗原 癌胚抗原 

分 类 号：R445.1[医药卫生—影像医学与核医学]