血清C1q肿瘤坏死因子相关蛋白1水平与急性ST段抬高型心肌梗死患者预后的相关性研究  

Correlation between Serum Level of C1q/TNF-Related Protein 1 and Prognosis of Patients with Acute ST Segment Elevation Myocardial Infarction

作　　者：谷阳[1] 张鑫 张喜文[1] 李江津[1] GU Yang;ZHANG Xin;ZHANG Xi-wen;LI Jiang-jin(Department of Cardiology,the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University,Huaian 223300,Jiangsu,China)

机构地区：[1]淮安市南京医科大学附属淮安第一医院心内科,江苏淮安市223300

出　　处：《中国分子心脏病学杂志》2022年第1期4427-4431,共5页Molecular Cardiology of China

基　　金：中华国际医学交流基金会整合思维研究基金(z-2016-23-2101-46);南京医科大学附属淮安第一医院科研启动经费项目(YGRS202006)。

摘　　要：目的 研究急性ST段抬高型心肌梗死(ST segment elevation myocardial infarction,STEMI)患者的血清C1q肿瘤坏死因子相关蛋白1(C1q/TNF-related protein 1,CTRP1)水平与预后的相关性。方法 选取2018年1月至2020年1月在我院就诊的急性STEMI患者205例,检测血清CTRP1水平,出院后随访1年。分析患者出院后1年内发生主要不良心血管事件(major adverse cardiovascular events,MACE)的影响因素,探讨CTRP1预测患者发生MACE的诊断价值。结果 发生MACE的急性STEMI患者年龄较大,左室射血分数(left ventricular ejection fraction,LVEF)较低,CTRP1水平和GRACE评分更高,梗死相关动脉多为左前降支,院外服用β受体阻滞剂的比例较低(P <0.05)。Logistic回归分析显示,年龄、LVEF、CTRP1、GRACE评分、口服β受体阻滞剂是急性STEMI患者出院后1年内发生MACE的独立预测因素(P <0.05)。CTRP1预测患者发生MACE的受试者操作特征曲线下面积为0.803(P <0.05)。结论 急性STEMI患者的血清CTRP1水平与远期预后具有密切的相关性。Objective To investigate the association between serum level of C1q/TNF-related protein 1(CTRP1) and prognosis of patients with acute ST segment elevation myocardial infarction(STEMI).Methods A total of 205 patients with acute STEMI from January 2018 to January 2020 were selected in the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University.The serum levels of CTRP1 were measured.The subjects were followed up for 1 year after discharge.We analyzed the influencing factors of major adverse cardiovascular events(MACE) within 1 year after discharge and explored the diagnostic value of CTRP1 in predicting the occurrence of MACE of acute STEMI patients.Results The patients with MACE were significantly older,with lower level of left ventricular ejection fraction(LVEF)and lower percentage of taking β blockers out of hospital.These patients had higher levels of CTRP1 and GRACE score and their infarction related arteries(IRA) were mainly left anterior descending(LAD)(P<0.05).Multivariate logistic regression analysis showed that age,the levels of LVEF,CTRP1 and GRACE score and taking β blockers were independently associated with MACE occurrence of acute STEMI patients within 1 year after discharge(P <0.05).Meanwhile,the receiver operator characteristic(ROC) curve of CTRP1 predicting MACE occurrence showed that the area under curve were 0.803(P<0.05).Conclusion There is an obvious relationship between the serum level of CTRP1and long-term prognosis of patients with acute STEMI.

关 键 词：急性ST段抬高型心肌梗死 C1q肿瘤坏死因子相关蛋白1 预后 

分 类 号：R542.22[医药卫生—心血管疾病]