M2a巨噬细胞在过敏性哮喘发病机制中的研究进展  

Advance of M2a macrophages in pathogenesis of allergic asthma

作　　者：邓珊 孔晓丹(指导)[1] DENG Shan;KONG Xiaodan(The Second Affiliated Hospital,Dalian Medical University,Dalian 116023,China)

机构地区：[1]大连医科大学附属第二医院,大连116023

出　　处：《中国免疫学杂志》2022年第6期758-761,共4页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(8194030);辽宁省自然科学基金项目(2019-BS-068)资助。

摘　　要：巨噬细胞极化在过敏性哮喘发病中起重要作用。巨噬细胞被IL-4和IL-13激活后成为替代活化型巨噬细胞(AAM)或M2细胞,其中M2a巨噬细胞在哮喘中的作用备受关注。阐明M2a细胞特异性蛋白在哮喘发病机制中的作用,有助于理解IL-4诱导的巨噬细胞在过敏性哮喘中的作用。本文对不同人M2a巨噬细胞标志物(包括表面标志物、酶、趋化因子和细胞因子)在过敏性哮喘发病机制中的作用进行综述。AAM在哮喘发病中既有保护性也有致病性作用,是过敏性哮喘的双刃剑。Macrophage polarization has been heavily associated with development of allergic asthma.Macrophages activated by IL-4 and IL-13 are called alternatively activated macrophages(AAM)or M2 cells.Role of M2a macrophages in asthma is a major concern.It's helpful to improve knowledge about role of IL-4-induced macrophages in allergic asthma,through elucidation of roles of specific M2a proteins in pathogenesis of asthma.This article reviewed different functions of M2a proteins and markers in pathogenesis of allergic asthma,including surface markers,enzymes,chemokines and cytokines.AAM is considered a double-edged sword in allergic asthma,acting protective and pathogenic roles in pathogenesis of asthma.

关 键 词：过敏性哮喘 巨噬细胞 发病机制 

分 类 号：R562.25[医药卫生—呼吸系统]