液质联用技术在抗生素分析中的应用  

Application of Liquid-mass Spectrometry in Antibiotic Analysis

作　　者：杨青 田冶[1] 江志钦 刘颖[1] 尹利辉[1] YANG Qing;TIAN Ye;JIANG Zhi-qin;LIU Ying;YIN Li-hui(National Institutes for Food and Drug Control,Beijing 100050,China)

机构地区：[1]中国食品药品检定研究院,北京102629

出　　处：《中国药物评价》2022年第2期113-118,共6页Chinese Journal of Drug Evaluation

基　　金：国家药品监督管理局化学药品质量研究与评价重点实验室科研项目资助(1030050090119)。

摘　　要：液质联用技术是将液相色谱与质谱串联的检测技术,具有灵敏度高、选择性好、分离能力强和高通量筛查的优点,已成为药物分析的关键技术和研究手段。通过简要综述了抗生素发展、应用中存在的问题以及液质联用技术在抗生素杂质研究、滥用残留及代谢方面的应用,为抗生素质量控制和合理使用提供相关理论参考。Liquid chromatography-tandem mass spectrometry(LC-MS/MS)is a combination of liquid chromatography and mass spectrometry,which is sensitivity,selectivity,strong separation ability and high throughput screening.LC-MS/MS has become the key technology and research means of drug analysis.This paper briefly reviewed the development and problem of antibiotics and the application of LC-MS/MS in the quality control,abuse residue and metabolism of antibiotics,providing relevant theoretical reference for the quality control and rational use of antibiotics.

关 键 词：液质联用技术 抗生素 杂质研究 滥用残留 抗生素代谢 

分 类 号：R927[医药卫生—药学]