孕期地塞米松暴露对大鼠生长发育的影响  

Effects of Dexamethasone Exposure during Pregnancy on Growth and Development of Rats

作　　者：贺雨晴 王好 谭靓 李默涵 王小冰 郭自景 HE Yu-qing;WANG Hao;TAN Liang;LI Mo-han;WANG Xiao-bing;GUO Zi-jing(Xiangnan University,Hunan Chenzhou 423000,China;"Biomedical Microbiology"Key Laboratory of Colleges And Universities,Hunan Chenzhou,China)

机构地区：[1]湘南学院药学院,湖南郴州423000 [2]“生物医药微生物组学”湖南省高校重点实验室,湖南郴州423000

出　　处：《中国药物评价》2022年第2期153-156,共4页Chinese Journal of Drug Evaluation

基　　金：国家级大学生创新创业训练计划(项目编号:S202010545036,项目名称:孕期地塞米松暴露对新生大鼠心脏的影响)。

摘　　要：目的:探讨孕期地塞米松暴露对孕鼠和胎鼠心脏、肾脏、肝脏和肺脏质量的影响。方法:妊娠期SD大鼠分为对照组和地塞米松组,在孕9~20 d期间,对照组大鼠肌注0.9%的氯化钠注射液0.2 mL·d^(-1),地塞米松组大鼠肌注地塞米松磷酸钠注射液0.2 mL·kg^(-1)·d^(-1)。妊娠20 d麻醉后剖腹取胎,测量孕鼠和胎鼠的体质量、心脏、肝脏、肾脏和肺脏质量。结果:与对照组相比,地塞米松组孕鼠的体质量增长率在孕9~17 d均显著降低(P<0.05),其肝脏和肺脏的质量均显著降低(P<0.01);胎鼠的体质量、心脏、肾脏、肝脏和肺脏的质量均显著降低,胎鼠肺脏和肝脏的脏器系数显著降低(P<0.01)。结论:孕期地塞米松暴露不仅可影响孕鼠肝脏和肺脏的发育,也影响胎鼠心脏、肾脏、肝脏和肺脏的生长发育。Objective:To investigate the effects of dexamethasone exposure during pregnancy on pregnant rats and fetal rats.Methods:SD rats during pregnancy were divided into control group and dexamethasone experimental group.During pregnancy 9-20 days,rats in the control group were intramuscularly injected with 0.9%sodium chloride injection 0.2 mL·d^(-1),and rats in the dexamethasone experimental group were intramuscularly injected with dexamethasone sodium phosphate injection 0.2 mL·kg^(-1)·d^(-1).The fetuses were collected by laparotomy after anesthesia on the 20th day of pregnancy,and the body weights,heart,liver,kidney and lung weights of pregnant and fetuses were measured.Results:Compared with the control group,the body mass growth rates of pregnant rats in the dexamethasone experimental group were significantly reduced from 9 to 17 days of pregnancy(P<0.05),while the quality of their liver and lungs were significantly reduced(P<0.01).The body mass,heart,liver,kidney and lungs of fetal rats in the dexamethasone experimental group were significantly reduced,and the organ coefficients of the lungs and liver were also significantly reduced(P<0.01).Conclusion:Dexamethasone exposure during pregnancy can not only affect the development of liver and lung in pregnant rats,but also affect the growth and development of heart,kidney,liver and lung in fetal rats.

关 键 词：地塞米松 孕期 肝脏 肾脏 心脏 肺脏 

分 类 号：R965[医药卫生—药理学]