参元益气活血胶囊对大鼠心肌缺血再灌注损伤的影响  

Effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury in rats

作　　者：刘冬平[1] 廖磊[1] 李蜀平[1] 刘魁英[1] 刘倩 孙道涵 佟彤[2] 刘红旭[2] LIU Dong-ping;LIAO Lei;LI Shu-ping;LIU Kui-ying;LIU Qian;SUN Dao-han;TONG Tong;LIU Hong-xu(Beijing Institute for Clinical Pharmacy Research,Beijing 100035,China;Department of Cardiovascular Internal Medicine,Beijing Hospital of Traditional Chinese medicine Affiliated to the Capital Medical University,Beijing 100010)

机构地区：[1]北京市临床药学研究所,北京100035 [2]首都医科大学附属北京中医医院心血管内科,北京100010

出　　处：《北京中医药》2022年第2期132-135,共4页Beijing Journal of Traditional Chinese Medicine

基　　金：北京市科委课题(Z141100002214010)。

摘　　要：目的观察参元益气活血胶囊对大鼠心肌缺血再灌注损伤(MIRI)的影响。方法SD大鼠分为假手术组、模型组、复方丹参片1.26 g/kg(对照组)和参元益气活血胶囊低(1.08 g/kg)、中(2.16 g/kg)、高(4.31 g/kg)剂量组。采用大鼠结扎冠状动脉左前降支30 min,再灌注120 min制备MIRI模型,测定血清AST、LDH、CK-MB、CK、Na^(+)-K^(+)-ATPase、Ca^(2+)-Mg^(2+)-ATPase、PGI2、TX-A2、SOD、MDA水平。结果与模型组比较,参元益气活血胶囊高剂量组可明显抑制血清中AST、CK、LDH、TX-A2、MDA的释放,提高Na^(+)-K^(+)-ATPase、Ca^(2+)-Mg^(2+)-ATPase、PGI2、SOD活力(P<0.01,P<0.05);参元益气活血胶囊中剂量组可明显抑制血清中CK、LDH的释放,提高SOD活力(P<0.01,P<0.05)。结论参元益气活血胶囊对MIRI大鼠心肌具有保护作用。ObjectiveTo observe the effect of Shenyuan Yiqi Huoxue Capsule on myocardial ischemia-reperfusion injury(MIRI)in rats.MethodsSD rats were randomly divided into sham,model,Compound Danshen Tablet 1.26 g/kg (control group) and Shenyuan Yiqi Huoxue Capsule groups of low dosage 1.08 g/kg,medium dosage 2.16 g/kg,and large dosage 4.31 g/kg.The MIRI model was established by the ligation of the left anterior descending coronary artery 30 min and the release 120 min in rats.Serum AST,LDH,CK-MB,CK,Na^(+)-K^(+)-ATPase,Ca^(2+)-Mg^(2+)-ATPase,PGI2,TX-A2,SOD,MDA were measured.Results Compared with the model group,Shenyuan Yiqi Huoxue Capsule group of high dosage can significantly inhibit serum AST,CK,LDH,TX-A2 and MDA content,improve Na^(+)-K^(+)-ATPase,Ca^(2+)-Mg^(2+)-ATPase,PGI2 and SOD activity(P<0.01,P<0.05);medium group can inhibit serum CK and LDH content,improve SOD activity (P<0.01,P<0.05).Conclusion Shenyuan Yiqi Huoxue Capsule has a protective effect on MIRI myocardium in rats.

关 键 词：参元益气活血胶囊 心肌缺血再灌注损伤 心肌酶 大鼠 

分 类 号：R285.5[医药卫生—中药学]