Syntheses,Crystal Structures and DNA-Binding Properties of Zn(Ⅱ)and Mn(Ⅱ)Complexes Based on Imidazole Derivatives and Carboxylic Acid  

作　　者：GUAN Hui-Chao SONG Xiao-Tong LIU Gui-Bao YUE Shu-Mei 关慧超;宋晓彤;刘贵宝;岳淑美(College of Chemistry,Changchun Normal University,Changchun 130032,China)

机构地区：[1]College of Chemistry,Changchun Normal University,Changchun 130032,China

出　　处：《Chinese Journal of Structural Chemistry》2022年第3期260-269,I0014,共11页结构化学（英文）

摘　　要：Complexes[Zn(pbm)(5-hip)_(3)](1),[Zn(pbm)(5-nip)3](2),[Mn(pbm)(H_(3)btc)_(2)(H_(2)O)](3)and[Mn(pbm)(5-nip)_(3)](4),where H2HIPA=5-hydroxyisophthalic acid,H2nip=5-nitroisophthalic acid,H3btc=tri-mesic acid and pbm(pyridine benzene chelate material)=2-(2-pyridyl)benzimidazole,were identified via sin-gle-crystal XRD analyses.1,2 and 4 pertain to the monoclinic space group C2/c,while 3 belongs to the triclinic space group P1.The interplay of CT-DNA with those complexes was delineated using ultraviolet,fluorescence,and circular dichroism(CD)spectroscopy and viscosity measurements.Complexes 1,2,3 and 4 interact with CT-DNA in an electrostatic or grooving mode.We wish to offer a theory-wise foundation for developing anti-tumor medi-cines.

关 键 词：single-crystal structures spectroscopy CT-DNA binding 2-(2-pyridyl)benzimidazole 

分 类 号：O641.4[理学—物理化学] TQ460.1[理学—化学]