纳米颗粒对免疫细胞调控的研究进展  

Research advance of nanoparticle regulation on immune cells

作　　者：陈方如[1] 黎振航 CHEN Fangru;LI Zhenhang(Department of Dermatology,Affiliated Hospital of Guilin Medical College,Guilin 541001,China)

机构地区：[1]桂林医学院附属医院皮肤性病科,541001

出　　处：《免疫学杂志》2022年第5期456-460,共5页Immunological Journal

基　　金：国家自然科学基金项目(81760562);广西壮族自治区卫生与计划生育委员会计划课题(Z2016383)。

摘　　要：特异性免疫治疗已成为预防和治疗多种疾病的有效策略,如肿瘤、自身免疫病等。近年来,研究人员不断探索具有新结构和新性能的纳米颗粒在临床的应用。本文综述了纳米颗粒通过调控调节性T细胞、自然杀伤细胞及树突状细胞等在维持自身免疫稳态方面的作用,可能成为未来治疗肿瘤、自身免疫病等的新策略。Specific immunotherapy has become an effective strategy to prevent and treat various of diseases,such as tumors,autoimmune diseases and so on.In recent years,researchers have been exploring the clinical application of nanoparticles with new structures and properties.This paper reviews the role of nanoparticles in maintaining autoimmune homeostasis by regulating regulatory T cells,natural killer cells and dendritic cells,which may be a new strategy for the treatment of tumors and autoimmune diseases in the future.

关 键 词：纳米颗粒 免疫治疗 调节性T细胞 自然杀伤细胞 树突状细胞 

分 类 号：R392.1[医药卫生—免疫学]