不同肿瘤浸润淋巴细胞亚型在三阴性乳腺癌中的研究进展  

Research progress of different tumor-infiltrating lymphocyte subtypes in triple-negative breast cancer

作　　者：杨怀玉 宣立学 Yang Huaiyu;Xuan Lixue(Department of Breast Surgical Oncology,National Cancer Center,National Clinical Research Center for Cancer,Cancer Hospital,Chinese Academy of Medical Sciences&Peking Union Medical Colkge,Beijing 100021,China)

机构地区：[1]国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院,北京100021

出　　处：《中华内分泌外科杂志》2022年第2期237-240,共4页Chinese Journal of Endocrine Surgery

摘　　要：目的三阴性乳腺癌被认为是侵袭性最强的乳腺癌亚型,因其缺乏雌激素受体(ER)、孕激素受体(PR)和HER2的表达,目前仍缺少比较明确的评判预后及指导治疗的生物标志物。随着肿瘤免疫学的进展,肿瘤免疫微环境与肿瘤发生发展之间的关系逐渐得到重视。越来越多的证据证明三阴性乳腺癌病灶中肿瘤浸润淋巴细胞(tumor-infiltrating lymphocytes,TIL)浸润水平越高,患者的预后越好。但TIL并非单一亚型细胞,其不同的淋巴细胞亚群在三阴性乳腺癌患者中的预后预测作用差异较大。本文总结了肿瘤免疫微环境中不同免疫细胞亚群与TNBC患者预后的关系。Triple-negative breast cancer is considered to be the most aggressive subtype of breast cancer.Due to its lack of expression of estrogen receptor(ER),progesterone receptor(PR)and HER-2,there is still a lack of clear prognostic judgments and biomarkers that guide treatment.With the development of tumor immunology,the relationship between tumor immune microenvironment and tumor occurrence and development has gradually gained attention.More and more evidence suggests that the higher the level of tumor-infiltrating lymphocytes(TIL)infiltration in triple-negative breast cancer lesions,the better the prognosis of patients.However,TIL is not a single type of cell,and its different lymphocyte subpopulations have different prognostic effects in patients with triple-negative breast cancer.This article summarizes the relationship between different immune cell subgroups in the tumor immune microenvironment and the prognosis of TNBC patients.

关 键 词：三阴性乳腺癌 肿瘤微环境 肿瘤浸润淋巴细胞 

分 类 号：R655.8[医药卫生—外科学] R737.9[医药卫生—临床医学]