哺乳动物种间嵌合体的研究进展  

Recent progress in the study of mammalian interspecies chimera

作　　者：张景瑶 闫鑫鹏 高帅[1] 张鲁[1] ZHANG Jingyao;YAN Xinpeng;GAO Shuai;ZHANG Lu(College of Animal Science and Technology,China Agriculture University,Beijing 100193,China;Ulanqab Livestock Husbandry Workstation,Ulanqab 012000,China)

机构地区：[1]中国农业大学动物科学技术学院,北京100193 [2]乌兰察布市畜牧工作站,内蒙古乌兰察布012000

出　　处：《黑龙江动物繁殖》2022年第2期32-37,共6页Heilongjiang journal of animal reproduction

基　　金：国家自然科学基金面上项目(31970814);国家重点研发计划项目“干细胞及转化研究”重点专项(2020YFA0113200);中国农业大学2115人才工程资助项目。

摘　　要：嵌合体是哺乳动物繁殖和发育研究的重要材料。利用嵌合体观察发育过程中细胞谱系和细胞命运的转变已经有悠久的历史,特别是与鉴定和产生各种多能性干细胞有关的研究,丰富了哺乳动物种间嵌合体的种类,为理解胚胎发育过程提供了新途径,加快了种间嵌合体临床应用的步伐。文章综述了哺乳动物种间嵌合体研究的起源与发展,并介绍了多能性干细胞对于种间嵌合体研究发展的推动作用,并展望了种间嵌合体的发展趋势和面临的问题。Chimeras are important materials for the study of mammalian reproduction and development.There has been a long history of using chimeras to tract cell lineage and cell fate transitions during development.Particularly advances related to the identification and generation of various pluripotent stem cells,has enriched the variety of mammalian interspecies chimeras,and provided new ways to understand embryonic development.The knowledge of chimeras accelerated the clinical application of organs generated from chimeras.This review introduces the origin and development of mammalian interspecies chimera research,and describes the role of pluripotent stem cells in driving the study of interspecies chimera research,and looks forward to the trends and issues facing interspecies chimeras.

关 键 词：种间嵌合体 胚胎干细胞 IPS细胞 进化距离 

分 类 号：S814.8[农业科学—畜牧学]