GSDMD介导的细胞焦亡在心血管疾病中的研究进展  

Research progress of GSDMD mediated pyroptosis in cardiovascular diseases

作　　者：单少鹏 李方[2] 郝恩魁 SHAN Shao-peng;LI Fang;HAO En-kui(Cheeloo College of Medicine,Shandong University,Jinan 250012,Shandong,China;Jinan Central Hospital,Jinan 250013,Shandong,China;Department of Cardiology,Qianfoshan Hospital,Shandong University,Jinan 250014,Shandong,China)

机构地区：[1]山东大学齐鲁医学院,济南250012 [2]济南市中心医院,济南250013 [3]山东大学附属千佛山医院(山东省千佛山医院)保健心内科,济南250014

出　　处：《中国临床医学》2022年第2期267-272,共6页Chinese Journal of Clinical Medicine

基　　金：山东省科技发展计划(2014GSF118187)。

摘　　要：焦亡是细胞死亡形式之一,与机体的先天免疫反应密切相关,以细胞膜通透性改变及释放炎性细胞因子为特征。GSDMD(gasdermin D)作为细胞焦亡过程中的关键分子,通过被半胱氨酸天冬酶激活而裂解成具有成孔活性的NH2-末端裂解产物(GSDMD-NT)和对其有抑制作用的COOH-末端裂解产物(GSDMD-CT),进而使炎性细胞因子释放,引起炎症反应。同时,氧化应激在细胞焦亡调节中起重要作用。目前,越来越多的研究发现细胞焦亡在动脉粥样硬化、心肌梗死、心脏缺血再灌注损伤、心肌炎、心肌病、心力衰竭等心血管疾病的发生发展中起重要作用。Pyroptosis has been found to be one of the ways of cell death.Pyroptosis is closely related to the innate immune response of the body,which is characterized by the changes of cell membrane permeability and the release of inflammatory cytokines.Gasdermin D(GSDMD),as a key molecule in the process of pyroptosis,is activated by caspase to cleave into a pore-forming NH2-terminal cleavage product(GSDMD-NT)and an inhibitory COOH-terminal cleavage product(GSDMD-CT),and inflammatory cytokines are further released and inflammatory reactions are induced.At the same time,oxidative stress plays an important role in the regulation of pyroptosis.At present,more and more studies have found that pyroptosis plays an important role in the occurrence and development of cardiovascular diseases such as atherosclerosis,myocardial infarction,myocardial ischemia-reperfusion injury,myocarditis,cardiomyopathy,heart failure,and so on.

关 键 词：细胞焦亡 GSDMD 氧化应激 心血管疾病 

分 类 号：R34[医药卫生—基础医学]