鸦胆子油乳注射液治疗宫颈癌及改善放化疗不良反应效果分析  

Analysis of the adverse effects of Brucea Javanica oil injection in the treatment of cervical cancer

作　　者：彭飞辉 李莉[1] 肖松舒[2] PENG Fei-hui;LI Li;XIAO Song-shu(Depart merit of Obstetrics and Gynecology,Changsha Fourth Hospital,Changsha 410000,China;Department of Obstetrics and Gynecology,the Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]长沙市第四医院妇产科,长沙410000 [2]中南大学湘雅三医院妇产科,长沙410013

出　　处：《临床药物治疗杂志》2022年第4期26-31,共6页Clinical Medication Journal

摘　　要：目的 观察鸦胆子油乳注射液对Ⅱb-Ⅲb宫颈癌患者临床疗效及放化疗不良反应的改善作用。方法 选取2020年9月至2021年3月长沙市第四医院确诊的宫颈癌患者,随机分为2组,对照组接受常规放化疗治疗,观察组在对照组基础上静脉滴注鸦胆子油乳注射液进行治疗。比较治疗4个疗程后两组患者的有效率,不良反应发生率以及肿瘤标志物水平。结果 共纳入患者96例,观察组和对照组各48例,治疗4个疗程后,观察组临床治疗有效率为83.33%,对照组为64.58%;观察组患者T细胞亚群及NK细胞较对照升高[CD_(3)^(+)观察组和对照组分别为62.0%±6.0%和57.7%±5.9%;CD_(4)^(+)观察组与对照组分别为42.1%±4.3%和40.2%±4.2%;CD_(8)^(+)观察组与对照组分别为33.0%±3.0%和28.7%±3.2%;NK细胞观察组与对照组分别为28.8%±3.0%和25.4%±2.8%],差异均有统计学意义(P<0.05)。观察组白细胞下降,恶心呕吐及腹痛、腹泻等不良反应发生率降低(P<0.05)。两组患者体内肿瘤标志物鳞状细胞癌抗原[观察组和对照组分别为(3.1±0.6)ng/mL和(5.1±0.7)ng/mL]、糖链抗原125[观察组和对照组分别为(22.5±2.6)U/mL和(35.3±3.2)U/mL]、糖链抗原19-9含量[观察组和对照组分别为(20.1±3.1)U/mL和(36.8±4.2)U/mL]均下降,差异有统计学意义(P<0.05)。结论 鸦胆子油乳注射液能提高Ⅱb-Ⅲb宫颈癌患者临床有效率,降低不良反应发生率并且降低肿瘤标志物水平。Objective To observe the clinical efficacy and radiotherapy and chemotherapy adverse reactions of Bruca Japonica oil emulsion injection on patients withⅡb-Ⅲb cervical cancer,in order to provide reference for the follow-up treatment.Methods Patients with cervical cancer diagnosed in Changsha Fourth Hospital from September 2020 to March 2021and were randomly divided into 2 groups.The control group received conventional radiotherapy and chemotherapy,and the observation group was treated with Brucea Japonica oil emulsion injection on the basis of the control group.The clinical remission rate,incidence of adverse reactions and the expression of tumor markers were compared between the two groups after 4 courses of treatment.Results A total of 96 patients withⅡb-Ⅲb cervical cancer were included,48 patients in the observation group and 48 patients in the control group.After 4 courses of treatment,the effective rate of clinical treatment in the observation group was 83.33%,while that in the control group was 64.58%.T cell subsets and NK cell in the observation group was significantly higher than the control group,the difference had statistics significance(P<0.05)[after CD_(3)^(+) treatment,observation group(62.0%±6.0%)vs control group(57.7%±5.9%);after CD_(4)^(+)treatment,observation group(42.1%±4.3%)vs control group(40.2%±4.2%);after CD_(8)^(+) treatment,observation group(33.0%±3.0%)vs control group(28.7%±3.2%);after NK cell treatment,observation group(28.8%±3.0%)vs control group(25.4%±2.8%)].The degree of leukopenia,nausea,vomiting,abdominal pain and diarrhea and other gastrointestinal reactions in the observation group were significantly reduced(P<0.05).The tumor markers squamous cell carcinoma antigen in the two groups[after treatment,observation group(3.06±0.65)ng/mL vs control group(5.1±0.7)ng/mL],sugar chain antigen 125[after treatment,observation group(22.5±2.6)U/mL vs control group(35.3±3.2)U/mL],sugar chain antigen 19-9 content[after treatment,observation group(20.1±3.1)U/mL vs control group

关 键 词：鸦胆子油 宫颈癌 临床缓解率 不良反应 

分 类 号：R979.19[医药卫生—药品] R969.3[医药卫生—药学]