慢性气道病患者深吸气量与健康相关生存质量的相关性研究  

Correlation of inspiratory capacity with health-related quality of life in patients with chronic airway diseases

作　　者：程梦真 陈翠翠[1] 王晓玥 宋元林[1] 侯东妮 Cheng Mengzhen;Chen Cuicui;Wang Xiaoyue;Song Yuanlin;Hou Dongni(Department of Pulmonary and Critical Care Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院呼吸与危重症医学科,上海200032

出　　处：《国际呼吸杂志》2022年第8期561-568,共8页International Journal of Respiration

基　　金：科技部国家重点研发计划(2020YFC2003700);上海市肺部炎症与损伤重点实验室项目(20DZ2261200);上海市临床重点专科建设项目(shslczdzk02201)。

摘　　要：目的探讨慢性阻塞性肺疾病(COPD)、哮喘及哮喘-慢阻肺重叠综合征(ACO)患者深吸气量(IC)与健康相关生存质量(HRQoL)的相关性,评估IC在HRQoL预测中的应用价值。方法采用多级分层整群抽样方法。将来自2012-2013年间中国肺部健康横断面随机分层抽样研究纳入的5271名上海市成人居民,根据肺功能结果分为COPD组、哮喘组、ACO组、其他慢性呼吸系统疾病组和健康组。收集的数据包括肺功能检查结果、健康调查12项简表(SF-12)和COPD CAT量表数据。采用Spearman相关系数评价肺功能指标与上述HRQoL量表结果的相关性。结果与COPD组比较,通气功能障碍在ACO组更重,哮喘组较轻(P值均<0.05)。在COPD组、ACO组、其他慢性呼吸系统疾病组和健康组中,IC均与年龄呈负相关(P值均<0.05)。在各组患者中IC与其他肺功能指标均呈正相关(P值均<0.05),且相关性在ACO组中最显著。ACO组中IC与SF-12躯体健康评分、CAT评分的相关性均较其他组更显著。ACO组中IC与CAT评分的负相关性较其他肺功能指标更显著(ρ=-0.45,P<0.001)。结论IC是影响ACO患者生存质量的重要肺功能指标,在评估ACO患者疾病严重程度中有应用价值。Objective To evaluate the correlation between inspiratory capacity(IC)and health-related quality of life(HRQoL)and assess the role of IC in predicting HRQoL in patients with chronic obstructive pulmonary disease(COPD),asthma,or asthma-COPD overlap syndrome(ACO).Methods Multilevel stratified cluster sampling method was used.We used a dataset of 5271 adult residents in Shanghai who participated in cross-sectional stratified random sampling China Pulmonary Health study between 2021 and 2013.Participants were classified into five groups including COPD,asthma,ACO,other pulmonary disease,and healthy group.Results of spirometry tests were used,and HRQoL were evaluated by 12-Item Short Form Survey(SF-12)and COPD assessment test(CAT).We evaluated the associations between parameters of spirometry test and HRQoL scores using Spearman correlation coefficient.Results Ventilatory dysfunction was more severe in ACO group,and relatively milder in asthma group when compared with COPD group.IC was negatively correlated with age in COPD,ACO,other pulmonary disease,and healthy group(all P<0.05).IC was positively correlated with other spirometry parameters in all groups(all P<0.05),with the correlation stronger in ACO group.IC was correlated with SF-12 score and CAT score in ACO group.For participants in ACO group,the correlation of IC with CAT score was stronger than with other spirometry parameters(ρ=-0.45,P<0.001).Conclusions Our study suggested that IC is an important spirometry parameter that is related to quality of life in ACO patients,thus IC should be underlined in assessing disease severity of ACO.

关 键 词：肺疾病 慢性阻塞性 哮喘-慢阻肺重叠综合征 哮喘 深吸气量 肺功能 健康相关生存质量 

分 类 号：R563.9[医药卫生—呼吸系统]