免疫调节细胞影响特发性肺纤维化的研究进展  

Progress in the study of immunoregulation affecting idiopathic pulmonary fibrosis

作　　者：魏婷 涂名进 郑斯平 伍俊 Wei Ting;Tu Mingjin;Zheng Siping;Wu Jun(Institute of Respiratory Diseases,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000,China)

机构地区：[1]广东医科大学附属医院呼吸疾病研究所,湛江524000

出　　处：《国际呼吸杂志》2022年第8期618-622,共5页International Journal of Respiration

基　　金：广东省自然科学基金(2020A1515010335)。

摘　　要：免疫细胞如巨噬细胞、中性粒细胞、嗜酸粒细胞和淋巴细胞等是机体抵御外来病原体入侵的先行军,在早期急性炎症和后期损伤修复中均发挥了重要的调节作用。近年研究发现免疫细胞的聚集、生长增殖和活化会加重慢性肺泡微损伤,导致损伤修复功能持续失调。这一系列免疫调节对特发性肺纤维化有驱动作用。因此,本文旨在回顾各种免疫细胞在特发性肺纤维化发病机制中的作用以及针对免疫细胞调节治疗特发性肺纤维化的最新研究报道。Immune cells such as macrophages,neutrophils,eosinophils,and lymphocytes play an important regulatory role in the early stage of acute inflammation and the later stage of injury repair.Recent studies have found that the aggregation,proliferation and activation of immune cells can aggravate the chronic alveolar microinjury.This series of immunomodulation can lead to idiopathic pulmonary fibrosis.Therefore,this paper is to review the roles of various immune cells in the pathogenesis of idiopathic pulmonary fibrosis and to review the latest research reports on immune cell regulation therapy for idiopathic pulmonary fibrosis.

关 键 词：特发性肺纤维化 免疫调节细胞 成纤维细胞 

分 类 号：R563[医药卫生—呼吸系统]