呼吸衰竭患者早期认知功能障碍的影响因素分析  

Influencing factors of early cognitive dysfunction in patients with respiratory failure

作　　者：范存永 冯志军[1] FAN Cunyong;FENG Zhijun(The First Affiliated Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学第一附属医院,开封475000

出　　处：《国际精神病学杂志》2022年第2期275-277,281,共4页Journal Of International Psychiatry

基　　金：2018年度河南省医学科技攻关计划项目(编号:2018010018)。

摘　　要：目的探讨分析呼吸衰竭患者早期认知功能障碍的影响因素。方法选择本院2018年11月~2020年10月收治的150例呼吸衰竭患者为主要研究对象,采取蒙特利尔认知功能评估量表(MoCA)对患者认知功能进行评价,总分>26分者分为正常组,总分≤26分者分为障碍组。观察比较两组患者的一般资料、急性生理与慢性健康评分(APACHCE-II)、序贯器官衰竭评分(SOFA)、脑利钠肽(BNP)、肺功能。采用多元Logistic回归分析法分析其可能的影响因素。结果150例患者中,MoCA总分>26分者62例,MoCA总分≤26分者88例。多元Logistic回归分析结果显示,年龄>60岁、神经中枢疾病、APACHCE-II>50分、SOFA>15分、BNP>60pg/ml、一秒用力呼吸容积(FEV1)≤50%、用力肺活量(FVC)≤2L均是呼吸衰竭患者早期认知功能障碍的风险因素(P<0.05)。结论高龄、神经中枢病变、BNP过高、肺功能较低是呼吸衰竭患者早期认知功能障碍可能的独立影响因素。Objective To investigate the influencing factors of early cognitive dysfunction in patients with respiratory failure.Methods A total of 150 patients with respiratory failure from November 2018 to October 2020 in our hospital were selected as the investigation subjects,and their cognitive function was evaluated using the Montreal Cognitive Assessment Scale(MoCA),and those with a total score>26 points were classified as the normal group,and those with a total score≤26 points were classified as the impaired group.The basic data,acute physiology and chronic health score(APACHCE-II),sequential organ failure assessment(SOFA),brain natriuretic peptide(BNP),and lung function were compared between the two groups.Multiple Logistic regression analysis was used to analyze the possible influencing factors.Results Among the 150 patients,62 patients had a>score of 26 in MOCA,and 88 patients had a>score of less than 26.Multiple Logistic regression analysis showed that age>60 years old,nerve center disease,Apachce-II>50 points,SOFA>15 points,BNP>60pg/ml,FEV1≤50%,FVC≤2L were all risk factors for early cognitive dysfunction in patients with respiratory failure(P<0.05).Conclusion Old age,neurocentral pathological changes,high BNP and low lung function were independent influencing factors for early cognitive dysfunction in patients with respiratory failure.

关 键 词：呼吸衰竭 认知功能障碍 影响因素 肺功能 

分 类 号：R749.23[医药卫生—神经病学与精神病学]