3D打印聚醚醚酮材料修复颅骨缺损  

3D printed polyetheretherketone material for skull defect repair

作　　者：翟红洁 韩冠达 李磊[1] 董小辉 姜之全[1] 娄飞云[1] Zhai Hongjie;Han Guanda;Li Lei;Dong Xiaohui;Jiang Zhiquan;Lou Feiyun(Department of Neurosurgery,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,Anhui Province,China)

机构地区：[1]蚌埠医学院第一附属医院神经外科,安徽省蚌埠市233000

出　　处：《中国组织工程研究》2023年第3期380-384,共5页Chinese Journal of Tissue Engineering Research

基　　金：安徽省自然科学基金项目(KJ2018A0995),项目负责人:姜之全。

摘　　要：背景:在进行颅骨重建过程中,采用不同颅骨修补材料的术后效果有一定区别,术后并发症的发生也有较大差异。目的:探讨采用3D打印聚醚醚酮材料行颅骨缺损成形的临床效果。方法:选择蚌埠医学院第一附属医院2016年2月至2020年8月收治的112例颅骨缺损患者,其中男67例,女45例,均进行颅骨重建手术,其中36例使用3D打印聚醚醚酮材料,76例使用三维钛网材料。术后随访观察两组并发症发生情况,包括皮下积液、脑积水、硬膜外或硬膜下血肿、切口愈合不良或植入物外漏、感染等。结果与结论:①聚醚醚酮组、钛网组患者分别获得术后(14.64±2.39),(15.49±2.17)个月随访,组间比较差异无显著性意义(P>0.05);两组均未出现因植入物材料原因导致植入失败的患者;②钛网组中33例患者出现并发症,其中1例为脑积水、9例为皮下积液、3例为硬膜外/下血肿、13例为切口愈合不良、3例为植入物外露、颅内感染4例,并发症发生率为43.4%;聚醚醚酮组中10例患者出现并发症,其中6例为皮下积液、1例为硬膜外/下血肿、2例为切口愈合不良、1例为颅内感染,并发症发生率为27.8%;两组术后总并发症发生率比较差异无显著性意义(P>0.05),但切口愈合不良/植入物外露发生率比较差异有显著性意义(P<0.05);③结果表明,3D打印聚醚醚酮修补材料在颅骨缺损修补应用中具有良好的生物相容性,且安全性、精确性较好,相对于钛网材料在切口愈合方面具有更好的优势。BACKGROUND:During cranioplasty,the postoperative effects of different cranial repair materials are different,and the occurrence of postoperative complications is also quite different.OBJECTIVE:To study the clinical effect of 3D printed polyetheretherketone material in cranioplasty.METHODS:112 patients with skull defect admitted to The First Affiliated Hospital of Bengbu Medical College from February 2016 to August 2020,including 67 males and 45 females,were selected and subjected to cranioplasty.The patients were divided into polyetheretherketone group(n=36)and titanium mesh group(n=76).Postoperative follow up was conducted to observe the occurrence of complications in the two groups,including subcutaneous effusion,hydrocephalus,epidural or subdural hematoma,poor wound healing,implant leakage,or infection.RESULTS AND CONCLUSION:(1)The patients in the polyetheretherketone group and titanium mesh group were followed up for(14.64±2.39)and(15.49±2.17)months after surgery,respectively,and there was no significant difference between the groups(P>0.05).There were no patients with implant failure due to implant material in either group.(2)Complications occurred in 33 patients in the titanium mesh group,including 1 case of hydrocephalus,9 cases of subcutaneous fluid,3 cases of epidural/subhematoma,13 cases of poor wound healing,and 3 cases of implant exposure,and 4 cases of intracranial infection.The complication rate was 43.4%.Totally 10 patients in the polyetheretherketone group had complications,including 6 cases of subcutaneous effusion,1 case of epidural/subhematoma,and 2 cases of poor wound healing,and 1 case of intracranial infection;the complication rate was 27.8%.There was no significant difference in the total postoperative complication rate between the two groups(P>0.05),but the incidence of poor wound healing/implant exposure was significantly different(P<0.05).(3)It is concluded that 3D printed polyetheretherketone repair material has good biocompatibility,safety and accuracy in the application of skull def

关 键 词：3D打印 聚醚醚酮 钛网 颅骨缺损 颅骨成形 并发症 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R651.11