不对称伤口敷料的研究进展与生物应用  

Advances and biological application of asymmetric dressings

作　　者：周洁 裴锡波 万乾炳[1] Zhou Jie;Pei Xibo;Wan Qianbing(Department of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610000,Sichuan Province,China)

机构地区：[1]四川大学华西口腔医院修复科,四川省成都市610000

出　　处：《中国组织工程研究》2023年第3期434-440,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81970984),项目负责人:万乾炳,项目名称:基于骨微环境设计的ZIF-8/SIM组织工程支架对于颌骨缺损的修复作用及其机制研究;国家自然科学基金面上项目(82071164),项目负责人:裴锡波,项目名称:miR-21@ZIF-8复合体协同调控β-catenin促进糖尿病骨病骨缺损修复的作用机制研究。

摘　　要：背景:使用伤口敷料对清创后的伤口进行保护已是许多学者的共识,但目前仍缺乏能模拟皮肤结构的理想多功能敷料。不对称伤口敷料能尽可能模拟天然皮肤结构,具有抗感染、促伤口渗出液排出等功能,有较大的潜力成为理想的伤口敷料。目的:总结不对称敷料的最新研究进展及生物应用。方法:利用计算机在PubMed、Web of Science、中国知网、万方数据库中进行文献检索,英文检索关键词为“asymmetric dressing,wound asymmetric membrane,wound asymmetric film”,中文检索关键词为“不对称敷料,伤口不对称膜”,根据纳入排除标准对文章进行筛选,最终纳入53篇文献进行综述。结果与结论:不对称敷料除可仿生天然皮肤的不对称结构外,其致密疏水层还能防止外界细菌侵入,控制创面水汽交换,亲水层能负载并释放需要的药物,多孔结构也利于细胞的黏附增殖,进而促进伤口愈合;其不对称特性并不能显著影响敷料的物理性能,但不对称敷料常由多种材料复合而成,所得的敷料性能常优于单一材料。目前的不对称敷料依照结构特点可分为单层改性不对称敷料、双层不对称敷料、梯度不对称敷料3种类型,今后的研究还会赋予不对称敷料更多、更智能的功能,使其作为一种可能的理想伤口敷料进一步发展,解决目前传统敷料在临床运用中所面临的问题。BACKGROUND:It has been a consensus to use wound dressings to protect and promote wound healing after debridement,but now there is no ideal multifunctional dressing that can simulate the skin structure.Asymmetric dressings can mimic the skin structure to the greatest extent,resistant to infection,control the water vapor exchange and promote the efflux of exudate.Therefore,asymmetric dressings have a great potential to become a kind of ideal wound dressings.OBJECTIVE:To summarize the latest research progress and biological application of asymmetric dressings.METHODS:The literature search was performed in PubMed,Web of Science,CNKI and Wanfang databases,and the keywords were“asymmetric dressing,wound asymmetric membrane,wound asymmetric film”in Chinese and English.The articles were screened according to the inclusion and exclusion criteria.Finally,53 articles were included for review.RESULTS AND CONCLUSION:Asymmetric dressings can simulate the structure of human skin,besides,its density hydrophobic layer can prevent invasion of external bacterium and control the exchange of water vapor.The hydrophilic layer is able to load and release the required drugs.The porous structure is conducive to cell proliferation and adhesion,thus promoting wound healing.The asymmetric characteristics do not significantly affect the physical properties of the asymmetric dressings,but these dressings are usually composed of multiple materials,resulting in better properties than single material.According to their structural characteristics,current asymmetric dressings can be divided into three types:single-layer modified asymmetric dressings,double-layer asymmetric dressings and gradient asymmetric dressings.In the future work,asymmetric dressings will be endowed with more and more intelligent functions and will be further developed as a potential ideal skin substitute,to solve the problems faced by traditional dressings in clinical application.

关 键 词：不对称敷料 新型伤口敷料 梯度敷料 抗感染 载药系统 Janus膜 伤口愈合 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R1