羧甲基壳聚糖在口腔组织工程中的应用  

Application of carboxymethyl chitosan in tissue engineering of stomatology

作　　者：宗明锐 刘海燕 李冰[1] 武秀萍[1] Zong Mingrui;Liu Haiyan;Li Bing;Wu Xiuping(School of Stomatology·Stomatology Hospital of Shanxi Medical University,Shanxi Provincial Key Laboratory of Oral Disease Prevention and New Materials,Taiyuan 030000,Shanxi Province,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室,山西省太原市030000

出　　处：《中国组织工程研究》2023年第3期447-452,共6页Chinese Journal of Tissue Engineering Research

基　　金：山西省高等学校科技创新项目(2020L0212),项目负责人:刘海燕;山西省回国留学人员科研资助项目(HGKY2019-055),项目负责人:李冰。

摘　　要：背景:作为天然生物材料壳聚糖的一种衍生物,羧甲基壳聚糖具有独特的水溶性、成膜性、缓释性,在组织工程领域具有广阔的应用前景。目的:综述羧甲基壳聚糖相较于壳聚糖的优势以及在口腔组织再生方面的应用。方法:利用计算机检索PubMed、中国知网数据库相关文献,中文检索词“羧甲基壳聚糖AND组织工程,羧甲基壳聚糖AND口腔医学”,英文检索词“carboxymethyl chitosan AND tissue engineering,carboxymethyl chitosan AND(dentistry OR stomatology)”,检索时限为2006年1月至2021年10月,通过阅读和分析文献进行初步筛选,以排除重复文献和低相关性文献,最终纳入文献51篇进行结果分析。结果与结论:羧甲基壳聚糖作为一种具有良好生物相容性、可降解的无毒材料,在骨组织再生、牙体组织再生、牙周组织再生方面已取得理想的进展。羧甲基壳聚糖相比壳聚糖具有更好的水溶性、成膜性和离子结合性,这极大扩展了其在口腔组织工程的应用。羧甲基壳聚糖单独使用可发挥抗菌效果,促细胞增殖、分化,或是作为支架材料、水凝胶、改性材料与生物活性成分和生长因子联合使用均达到了预期的实验效果。BACKGROUND:As a derivative of natural biological material chitosan,carboxymethyl chitosan has a wide application prospect in tissue engineering due to its unique water-solubility,film-forming and sustained-release properties.OBJECTIVE:To review the advantages of carboxymethyl chitosan compared with chitosan and its application in oral tissue regeneration.METHODS:PubMed and CNKI were searched using the key words of“carboxymethyl chitosan AND Tissue engineering,carboxymethyl chitosan AND(dentistry OR stomatology)”for articles published from January 2006 to October 2021.Preliminary screening was conducted through reading and analysis to exclude duplicate articles and low-correlation articles.Eventually,51 articles were included for result analysis.RESULTS AND CONCLUSION:Carboxymethyl chitosan,as a non-toxic material with valuable biocompatibility and biodegradation,has made ideal progresses in bone tissue regeneration,tooth tissue regeneration and periodontal tissue regeneration.Carboxymethyl chitosan has better water solubility,membrane formation and ion binding properties than chitosan,which greatly expands its application in oral tissue engineering.Carboxymethyl chitosan has achieved the expected experimental results whether it is used alone to exert antibacterial effect and promote cell proliferation and differentiation,or used as a scaffold material,hydrogel,modified material and biological active ingredients and growth factors.

关 键 词：羧甲基壳聚糖 壳聚糖衍生物 组织工程 口腔组织构建 牙周再生 再矿化 骨再生 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R78