济宁市2021年第一季度流感样病例病原谱特征分析  

Pathogen spectrum analysis of influenza-like illness in Ji’ning City,the first quarter of 2021

作　　者：王玉宁[1] 江亚娟 窦慧馨 范莹莹 尹强 焦伯延[1] WANG Yu-ning;JIANG Ya-juan;DOU Hui-xin;FAN Ying-ying;YIN Qiang;JIAO Bo-yan(Ji’ning Municipal Center for Disease Control and Prevention,Ji'ning,Shandong 272000,China)

机构地区：[1]济宁市疾病预防控制中心,山东济宁272000

出　　处：《中国卫生检验杂志》2022年第7期811-814,共4页Chinese Journal of Health Laboratory Technology

基　　金：山东省医药卫生科技发展计划项目(202112060725);济宁市重点计划研发项目[2021年医学研究和临床医学类(18)]。

摘　　要：目的了解济宁市2021年第一季度流感样病例中呼吸道病原体分布情况,为临床诊断和治疗提供参考依据。方法采集济宁市2021年第一季度208例流感样病例咽拭子标本,利用QIAstat-Dx全自动多重病原体检测平台检测23种常见呼吸道病原体。结果呼吸道病原体总检出率为20.67%(43/208),其中混合感染占6.98%(3/43)。病原体以病毒为主,占比97.67%(42/43),其中腺病毒(ADV)、肠道病毒(EV)、副流感病毒1(PIV1)、冠状病毒NL63(NL63)占比最高。不同月份和不同年龄组总检出率不同,其中1月份总检出率最高,为32.00%(24/75);0岁~5岁年龄组总检出率最高,为35.06%(27/77);而不同性别总检出率差异无统计学意义(χ^(2)=1.804,P=0.18)。结论2021年第一季度济宁市呼吸道病原体以ADV、EV、PIV1和NL63为主,应加强呼吸道病原体监测和防控力度,特别是低年龄组人群应当是监测的重点。Objective To understand the distribution and constitution of respiratory pathogens of influenza-like illness in Ji’ning City in the first quarter of 2021,and to provide scientific basis for clinical diagnosis and treatment.Methods A total of 208 throat swabs from influenza-like illness in Ji’ning were collected and 23 respiratory pathogens were detected by QIAstat-Dx automatic multiple pathogen detection platform.Results The total positive rate was 20.67%(43/208),and the mixed infection accounted for 6.98%(3/43).Virus was the main pathogen,accounting for 97.67%(42/43).Moreover,the detection rate of Adenovirus(ADV),Enterovirus(EV),Parainfluenza Virus 1(PIV1),Coronavirus NL63(NL63)were high.The total positive rates of between different age groups and different months were statistically different,with the highest observed in January(32.00%,24/75)and 0-5 age group(35.06%,27/77).However,the difference in the total positive rate between genders was not statistically significant(χ^(2)=1.804,P=0.18).Conclusion The main respiratory pathogens in Ji’ning in the first quarter of 2021 might be ADV,EV,PIV1,NL63.Surveillance and prevention of respiratory pathogens should be strengthened,especially in the low-age group.

关 键 词：流感样病例 呼吸道病原体 病毒 多重病原体检测 

分 类 号：R446[医药卫生—诊断学]