CYP2C9基因多态性在子痫前期产妇中的表达及其与妊娠结局的相关性研究  

Expression of CYP2C9 gene polymorphism in preeclampsia women and its correlation with pregnancy outcome

作　　者：秦帆 张盛燕 李晓红 QIN Fan;ZHANG Sheng-yan;LI Xiao-hong(Department of Obstetrics,Women’s and Children’s Branch,Rui’an People’s Hospital of Zhejiang Province,Rui’an,Zhejiang 325000,China)

机构地区：[1]浙江省瑞安市人民医院妇幼分院产科,浙江瑞安325000

出　　处：《中国卫生检验杂志》2022年第7期828-831,共4页Chinese Journal of Health Laboratory Technology

基　　金：温洲市科技局公益性社会发展(医疗卫生)科技项目(Y20170591)。

摘　　要：目的探讨CYP2C9基因多态性在子痫前期产妇中的表达及其与妊娠结局的相关性。方法选择2020年2月—2021年2月本院收治84例子痫前期产妇作为观察组,另选择健康产检80例正常孕妇作为对照组。通过TaqMan探针分析2组CYP2C9基因rs4918758位点等位基因,比较2组CYP2C9基因rs4918758位点等位基因(G、A)分布、妊娠结局及新生儿结局。结果84例子痫前期产妇中,突变纯合(*1G/*1G)16例(19.05%),杂合突变(*1/*1G)5例(8.33%),野生纯合(*1/*1)70例(72.62%),CYP2C9*1基因突变等位基因频率为27.38%。观察组患者剖宫产、流产、早产的发生率均明显高于对照组(P<0.05);2组患者产后出血发生率差异无统计学意义(P>0.05)。观察组新生儿窒息、新生儿透明膜病、NRDS发生率均高于对照组(P<0.05)。结论表达较高,且和产妇的妊娠结局关系密切,通过分析CYP2C9基因多态性的表达,能为临床探讨子痫前期发病机制和改善妊娠结局提供指导。Objective To investigate the expression of CYP2C9 gene polymorphism in preeclampsia women and its correlation with pregnancy outcome.Methods From February 2020 to February 2021,84 cases of pre-epilepsy women admitted to this hospital were selected as the observation group.In addition,80 cases of normal pregnant women were selected as the control group.The two groups of CYP2C9 gene rs4918758 alleles were analyzed by TaqMan probe,and theCYP2C9 gene rs4918758 locus alleles(G,A)distribution,pregnancy outcome and neonatal outcome were compared between the two groups.Results Among84 cases of preeclampsia women,16 cases(19.05%)were pure mutation(*1G/*1G),5 cases(8.33%)were heterozygous mutation(*1/*1G),and 70 cases(72.62%)were homozygous(*1/*1),and the CYP2C9*1 gene mutation allele frequency was 27.38%.The incidence of cesarean section,abortion and premature delivery in the observation group was higher than that in the control group,with the differences not statistically significant(P>0.05).The incidence of neonatal asphyxia,hyaline membrane disease and NRDS in the observation group were higher than those in the control group(P<0.05).Conclusion The CYP2C9 gene polymorphism is highly expressed in preeclampsia women and is closely related to the pregnancy outcome of the women.By analyzing the expression of CYP2C9 gene polymorphism,it can provide guidance for clinical exploration of the pathogenesis of preeclampsia and improvement of pregnancy outcome.

关 键 词：CYP2C9基因多态性 子痫前期 突变纯合 杂合突变 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]