2487例乙型肝炎病毒感染孕妇实验室指标特征及母婴阻断分析  

A study on characteristics of laboratory indexes and mother infant blocking in 2487 pregnant women with HBV infection

作　　者：王根芬 胡久琼 周绍真 苏胖胖 WANG Gen-fen;HU Jiu-qiong;ZHOU Shao-zhen;SU Pang-pang(Clinical Laboratory,Ninghai County Maternal and Child Health Care Hospital,Ninghai,Zhejiang 315600,China;不详)

机构地区：[1]宁海县妇幼保健院检验科,浙江宁海315600 [2]宁海县妇幼保健院妇产科,浙江宁海315600

出　　处：《中国卫生检验杂志》2022年第6期747-749,共3页Chinese Journal of Health Laboratory Technology

基　　金：宁海县科技计划项目(1906)。

摘　　要：目的回顾性研究孕妇乙型肝炎病毒(HBV)感染以及母婴传播阻断情况,分析HBV感染孕妇实验室指标特征以及母婴传播阻断方法。方法跟踪调查2017年1月—2020年12月在宁海县妇幼保健院就诊HBV阳性孕妇,收集孕妇资料,分析HBV-DNA水平、实验室ALT、TBil、BUN、CK指标以及产后新生儿HBV感染情况。结果宁海县地区孕妇HBV感染率为5.25%,呈逐年降低趋势(χ^(2)=24.016,P<0.01),>30岁孕妇HBV感染率显著高于≤30岁(χ^(2)=13.337,P<0.01)。实验室ALT指标异常最多,异常率占总HBV阳性孕妇的14.84%。HBV高载量孕妇抗病毒治疗比未进行抗病毒治疗母婴阻断成功率更高,差异有统计学意义(χ^(2)=5.855,P<0.05)。结论为保证HBV感染孕妇母婴健康需加强孕期实验室指标监测,HBV高载量孕妇孕期有必要进行抗病毒治疗,对于降低HBV母婴传播有重要意义。Objective To retrospectively study the HBV infection in pregnant women and the blocking of mother to child transmission,and analyze the characteristics of laboratory indexes and the blocking methods of mother to child transmission in pregnant women with HBV infection.Methods Follow up the investigation of HBV positive pregnant women in Ninghai Maternal and Child Health Care Hospital from January 2017 to December 2020,collect the data of pregnant women,and analyze the HBV-DNA level,laboratory alt,TBil,BUN,CK indicators and HBV infection of postpartum newborns.Results The HBV infection rate of pregnant women in Ninghai County was 5.25%,showing a decreasing trend year by year(χ^(2)=24.016,P<0.01).The HBV infection rate of pregnant women>30 years old was significantly higher than that≤30 years old(χ^(2)=13.337,P<0.01).The laboratory ALT index was the most abnormal,and the abnormal rate accounted for 14.84%of the total HBV positive pregnant women.The success of maternal and infant blocking was higher in pregnant women with high HBV load than that without antiviral treatment,with the differences statistically significant(χ^(2)=5.855,P<0.05).Conclusion In order to ensure the maternal and infant health of HBV infected pregnant women,it is necessary to strengthen the monitoring of laboratory indicators during pregnancy.It is necessary for HBV high load pregnant women to receive antiviral treatment during pregnancy,which is of great significance to reduce HBV mother to infant transmission.

关 键 词：乙型肝炎病毒 孕妇 谷丙转氨酶 母婴阻断 

分 类 号：R512.62[医药卫生—内科学]