熄风化痰定眩汤辅助治疗后循环缺血性眩晕痰瘀阻窍证临床观察  

Clinical Observation of Wind-Eliminating and Phlegm-Resolving and Vertigo-Calming Decoction in the Adjuvant Treatment of Posterior Circulation Ischemic Vertigo Syndrome of Phlegm and Blood Stasis Blocking Orifices

作　　者：赵本璐 张振华[1] 李靖[1] 曹锐[2] ZHAO Ben-lu;ZHANG Zhen-hua;LI Jing;CAO Rui(Chaoyang District Hospital of Traditional Chinese Medicine of Beijing,Beijing,China,100020;Beijing Chaoyang Hospital,Capital Medical University,Beijing,China,100020)

机构地区：[1]北京市朝阳区中医医院,北京100020 [2]首都医科大学附属北京朝阳医院,北京100020

出　　处：《河南中医》2022年第6期882-886,共5页Henan Traditional Chinese Medicine

基　　金：中国中医科学院中医基础理论研究所基本科研业务费自主选题项目(YZ-1930);北京市朝阳区中医药薪火传承学术经验暨特色技术继承工程项目{朝卫通字[2018]228号}。

摘　　要：目的:观察熄风化痰定眩汤辅助治疗后循环缺血性眩晕(posterior circulation ischemic vertigo,PCIV)痰瘀阻窍证的临床疗效及安全性。方法:选择2020年1月至2021年6月北京市朝阳区中医医院收治的60例后循环缺血性眩晕患者作为研究对象,采用随机数字表法分为对照组和观察组各30例。对照组给予甲磺酸倍他司汀片口服治疗,观察组在对照组治疗的基础上联用熄风化痰定眩汤治疗,两组均治疗4周。分别于治疗前后进行中医证候评分及眩晕评定量表(dizziness assessment rating scale,DARS)、眩晕障碍量表(dizziness handicap inventory,DHI)评分;采用经颅多普勒血流分析仪检测左侧椎动脉(left vertebral artery,LVA)、右侧椎动脉(right vertebral artery,RVA)和基底动脉(basilar artery,BA)的平均血流速度;记录治疗期间不良反应,评价临床疗效。结果:对照组有效率为73.33%,观察组有效率为93.33%,两组有效率比较,差异有统计学意义(P<0.05)。治疗后,观察组中医证候评分、眩晕评定量表评分、眩晕障碍量表评分均低于本组治疗前,且治疗后观察组评分低于对照组,差异有统计学意义(P<0.05);观察组LVA、RVA、BA平均血流速度均高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗期间未见明显不良反应。结论:熄风化痰定眩汤辅助治疗后循环缺血性眩晕痰瘀阻窍证,可有效改善患者临床症状及脑血流动力学状态。Objective:To observe the clinical efficacy and safety of Wind-Eliminating and Phlegm-Resolving and Vertigo-Calming Decoction in the adjuvant treatment of posterior circulation ischemic vertigo(PCIV).Methods:A total of 60 patients with PCIV treated in Chaoyang District Hospital of Traditional Chinese Medicine of Beijing from January 2020 to June 2021 were selected as the research subjects.They were randomly divided into the control group and the observation group,with 30 cases in each group.The control group was treated with Betahistine Mesylate Tablets orally,while the observation group was treated with Wind-Eliminating and Phlegm-Resolving and Vertigo-Calming Decoction on the basis of the treatment of the control group.Both groups were treated for 4 weeks.TCM syndrome score,dizziness assessment rating scale(DARS)and dizziness handicap inventory(DHI)were scored before and after treatment.Transcranial Doppler blood flow analyzer was used to detect the average blood flow velocity of left and right vertebral artery and basilar artery.The adverse reactions during treatment were recorded and the clinical efficacy was evaluated.Results:The effective rate was 73.33%in the control group and 93.33%in the observation group.There was significant difference between the two groups(P<0.05).After treatment,the scores of TCM syndrome,vertigo rating scale and vertigo disorder scale in the observation group were lower than those before treatment,and the above indexes of the observation group were lower than those of the control group,and all the differences were statistically significant(P<0.05).The average blood flow velocities of left vertebral artery(LVA),right vertebral artery(RVA)and basilar artery(BA)in the observation group were higher than those of the same group before treatment,and the above indexes of the observation group were higher than those of the control group after treatment,and all the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during treatment.Co

关 键 词：眩晕 后循环缺血 痰瘀阻窍证 熄风化痰定眩汤 甲磺酸倍他司汀片 中西医结合疗法 

分 类 号：R255.5[医药卫生—中医内科学]