参酱止露汤治疗药物流产后恶露不绝气虚血瘀证疗效观察  

Observation of Therapeutic Effect of Shenjiang Zhilu Decoction on Lochia After Abortion with Qi Deficiency and Blood Stasis Syndrome

作　　者：秦丹 代淑芳 陈绍林 QIN Dan;DAI Shu-fang;CHEN Shao-lin(Pingdingshan Maternal and Child Health Care Hospital,Pingdingshan,Henan,China,467000)

机构地区：[1]平顶山市妇幼保健院,河南平顶山467000

出　　处：《河南中医》2022年第6期914-918,共5页Henan Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2020JDZX2006)。

摘　　要：目的:观察参酱止露汤治疗药物流产后恶露不绝气虚血瘀证的临床疗效。方法:选择2020年1月至2021年6月在平顶山市妇幼保健院门诊治疗的产后恶露不绝患者为研究对象,共118例,按照随机数字表法分为对照组和观察组,每组各59例。对照组采用醋酸甲羟孕酮片口服治疗,观察组在对照组治疗的基础上加用参酱止露汤治疗,观察两组患者临床疗效及相关指标的变化情况。结果:对照组有效率为77.97%,观察组有效率为91.53%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组患者恶露持续时间、月经复潮时间短于对照组,差异有统计学意义(P<0.05)。观察组患者子宫底部下降程度与对照组比较,差异有统计学意义(P<0.05)。两组患者治疗后子宫体积均较治疗前明显减小,且观察组明显低于对照组,差异有统计学意义(P<0.05)。观察组卵巢、子宫搏动指数(pulse index,PI)、收缩期峰值流速(systolic peak flow rate,PSV)与对照组比较明显升高,阻力指数(resistance index,RI)值明显下降,差异有统计学意义(P<0.05)。两组患者治疗后纤维原蛋白(fibrinogen,Fib)、D-二聚体(d-dimer,D-D)含量均较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后血管生成素-1(angiogenin-1,Ang-1)、C反应蛋白(c-reactive protein,CRP)含量均较治疗前明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为8.47%,并发症发生率为16.95%,观察组不良反应发生率为3.39%、并发症发生率为6.78%,两组患者不良反应发生率及并发症发生率比较,差异均有统计学意义(P<0.05)。结论:参酱止露汤治疗产后恶露不绝,可有效缩短恶露排出时间,促进月经复潮、子宫复旧,改善卵巢、子宫微循环障碍,减轻炎症Objective:To observe the clinical efficacy of Shenjiang Zhilu Decoction(参酱止露汤,SJZLD)on lochia after abortion with qi deficiency and blood stasis syndrome.Methods:A total of 118 patients with lochia after abortion who were treated in the outpatient department of Pingdingshan Maternal and Child Health Hospital from January 2020 to June 2021 were selected as the research subjects.They were randomly divided into the control group and the observation group,with 59 cases in each group.The control group was treated with Medroxyprogesterone Aetate Tablets orally,while the observation group was treated with SJZLD on the basis of the treatment of the control group.The clinical efficacy and changes of relevant indexes of the two groups were observed.Results:The effective rate was 77.97%in the control group and 91.53%in the observation group.There was significant difference between the two groups(P<0.05).The TCM syndrome scores of the two groups after treatment were significantly lower than those before treatment,and the TCM syndrome score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The duration of lochia and menstrual rehydration in the observation group were significantly shorter than those in the control group,and all the differences were statistically significant(P<0.05).There was significant difference in the descending degree of the bottom of uterus between the observation group and the control group(P<0.05).The uterine volume of the two groups after treatment was significantly lower than that before treatment,and the observation group′s was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Compared with the control group,the pulse index(PI)and systolic peak flow rate(PSV)of ovary and uterus in the observation group increased significantly,and the resistance index(RI)decreased significantly,and all the differences were statistically significant(P<0.05).After

关 键 词：产后恶露不绝 气虚血瘀证 药物流产 参酱止露汤 醋酸甲羟孕酮片 中西医结合疗法 

分 类 号：R271.914.21[医药卫生—中西医结合]