不同高原环境暴露时间对甲状腺激素变化的影响  

Effects of Different Exposure Durations at High Altitudeon Thyroid Hormones

作　　者：贾倩[1] 陈卉宁 崔赛嘉 郝丽君 赵晓静[1] JIA Qian;CHEN Huining;CUI Saijia;HAO Lijun;ZHAO Xiaojing(Translational Medical Research Center,Chinese PAL General Hospital,Beijing 100853,China;Roche Diagnostic(Shanghai)Limited,Beijing 100005,China)

机构地区：[1]中国人民解放军总医院医学创新研究部转化医学研究中心,北京100853 [2]罗氏诊断产品(上海)有限公司,北京100005

出　　处：《标记免疫分析与临床》2022年第3期361-364,396,共5页Labeled Immunoassays and Clinical Medicine

基　　金：国家自然科学基金(编号:8200072521)。

摘　　要：目的研究不同高原环境暴露时间对健康成人甲状腺激素分泌的影响,并探讨平原汉族与高原世居藏族的甲状腺激素水平的差异。方法随机选取平原汉族及汉族进入高原(4300m)1周、6个月、1年的受试者,并选取同海拔水平的藏族世居者,分别采集他们的静脉血,使用罗氏电化学发光免疫法(ECLIA)检测甲状腺激素水平。结果与平原汉族受试者相比较,急进高原1周时T_(4)、FT_(3)、FT_(4)水平变化最为显著,但TSH无明显变化;高原习服1年后T_(3)、T_(4)、FT_(3)、FT_(4)趋于平稳,而TSH水平高于其他时间点。高原世居藏族受试者甲状腺激素水平高于平原汉族。结论甲状腺分泌的不同激素在不同高原暴露时间时具有不同的反应趋势。Objective To study the effects of different exposure durations at high altitude on thyroid hormones secretion in healthy adults,and to explore the differences of thyroid hormones levels between Han population in plain area and Tibetan population in plateau.Methods Subjects of Han population in plain area and Han population who entered the plateau(4300m)for 1 week,6 months and 1 year were randomly selected.The blood of Tibetans at the same altitude was collected,respectively.Thyroid hormones were measured by Roche ECLIA.Results Compared with the plain area Han subjects,T_(4),FT_(3) and FT_(4) changed most significantly when subjects entering the plateau for one week,but TSH did not change significantly.One year after plateau acclimatization,T_(3),T_(4),FT_(3) and FT_(4) tended to be stable,while TSH level was higher than other time points.All thyroid hormones of Tibetan subjects in plateau was higher than that of Han subjects in plain area.Conclusion Different levels of thyroid hormones have different response tendencies at different altitude exposure durations.

关 键 词：甲状腺激素 高原 暴露时间 藏族 

分 类 号：R446.1[医药卫生—诊断学]