非心肌损伤患者心肌标志物水平升高情况分析  

An Analysis of Elevated Levels of Cardiac Markers inPatients Without Myocardial Injury

作　　者：赖宇尧 张珊 李桂珊 廖守万 LAI Yuyao;ZHANG Shan;LI Guishan;LIAO Shouwan(Clinical Laboratory of Nan’ao People’s Hospital Dapeng New Distrisct,Shenzhen 518121,China)

机构地区：[1]深圳市大鹏新区南澳人民医院检验科,广东深圳518121

出　　处：《标记免疫分析与临床》2022年第3期405-407,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：目的结合临床诊断情况分析非心肌疾病患者肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTnI)检测结果升高原因,以便更好指导临床患者的诊治,避免误诊。方法选取2020年1月至2021年1月本院门诊及住院检测过CK、CKMB、cTnI患者的血清样本,结合临床诊断分析各指标升高的可能原因。结果38例cTnI假性升高的非心肌疾病患者,其中脑血管疾病及眩晕、意识障碍患者cTnI轻微升高,高血压患者中cTnI升高较明显;32例CK-MB mass假性升高的非心肌疾病患者,其中脑血管疾病及眩晕、意识障碍患者CK-MB mass升高较明显,在胃肠炎、呼吸道疾病和中毒患者中轻微升高。结论在非心肌疾病情况下,患者出现急性脑血管病、高血压、内脏损伤、脑缺血缺氧状态等情况,都可能导致cTnI和CK-MB mass的假性升高。Objective Combined with the clinical diagnosis,to investigate the reasons for the elevated test results of creatine kinase(CK),creatine kinase MB(CKMB)and cardiac troponin-I(cTnI)patients with non-cardiac diseases,so as to better guide the diagnosis and treatment of clinical patients and avoid misdiagnosis.Methods Serum samples of outpatient and inpatient patients with CK,CKMB and cTnI from January,2020 to January,2021 were selected to analyze the possible reasons for the increase of each index in combination with clinical diagnosis.Results cTnI increased slightly in patients with cerebrovascular disease,vertigo and consciousness disorder,and significantly increased in patients with hypertension.There were 32 patients with non-cardiac diseases with pseudo elevation of CK-MB mass,among which the elevation of CK-MB mass was significantly higher in patients with cerebrovascular diseases,vertigo and disturbance of consciousness,and slightly increased in patients with gastroenteritis,respiratory diseases and poisoning.Conclusion In non-cardiac disease,the occurrence of type cerebrovascular disease,hypertension,visceral injury,cerebral ischemia and hypoxia could lead to the false elevation of cTnI and CK-MB mass.

关 键 词：CTNI CK-MB mass 非心肌损伤 假性升高 

分 类 号：R446.1[医药卫生—诊断学]