肿瘤相关成纤维细胞在胃癌中的作用及研究进展  

Role and research progress in cancer-associated fibroblasts in gastric cancer

作　　者：魏金五 李桂香[1] Wei Jin-wu;Li Gui-xiang(Cancer Center,The Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院肿瘤中心,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2022年第4期66-71,共6页Journal of Lanzhou University（Medical Sciences）

摘　　要：胃癌是世界范围内发病率及死亡率位居前五的恶性肿瘤,是影响人类生命健康的主要癌症之一。胃癌的发生发展离不开其所处的肿瘤微环境。肿瘤相关成纤维细胞是肿瘤微环境中重要的组成部分,与肿瘤的发生、发展及治疗均有密切联系。本研究介绍了肿瘤相关成纤维细胞在胃癌中的来源和异质性,回顾了其在胃癌发生发展及治疗中的作用及最新研究进展,以期为胃癌发生发展机制研究及治疗提供新思路。Ranking among the top five cancers in terms of morbidity and mortality worldwide,gastric cancer is one of the dominant cancers threatening the life and health of people in China.The occurrence and development of gastric cancer is inseparable from the tumor microenvironment,in which cancer-associated fibroblasts constitute an essential part closely related to the occurrence,development and treatment of tumors.This paper introduced the origin and heterogeneity of cancer-associated fibroblasts in gastric cancer,reviewed their role and latest research progress in the occurrence,development and treatment of gastric cancer,in order to provide new ideas for the research on the mechanism and treatment of gastric cancer.

关 键 词：肿瘤相关成纤维细胞 肿瘤微环境 胃癌 

分 类 号：R446.1[医药卫生—诊断学]