髋关节广泛耐药性结核分枝杆菌感染诊治1例  

Diagnosis and treatment of extensively drug-resistant mycobacterium tuberculosis infection of hip joint:A case report

作　　者：李聪 李旭升 张浩强 李鹏 程永刚 叶铄 LI Cong;LI Xusheng;ZHANG Haoqiang;LI Peng;CHENG Yonggang;YE Shuo(Department of Joint Surgery,940th Hospital of PLA Joint Logistics Support Force,Lanzhou 730000;Medical College of Northwest MinzuUniversity,Lanzhou 730000;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院关节外科,兰州730000 [2]西北民族大学医学部,兰州730000 [3]甘肃中医药大学,兰州730000

出　　处：《临床与病理杂志》2022年第4期1002-1006,共5页Journal of Clinical and Pathological Research

基　　金：全军后勤科研计划面上项目(CWH17J009);中央高校基本科研业务费专项资金(31920200018);全军医学科技青年培育计划(19QNP047);甘肃省自然科学基金(18JR3RA403);甘肃省青年科技基金(18JR3RA410);甘肃省卫生行业科研计划项目(GSWSKY2018-21,GSWSKY2019-94);兰州市人才创新创业项目(2019-RC-65)。

摘　　要：髋关节广泛耐药性结核菌感染临床少见,其确诊所需时间较长,往往确诊时已为晚期,对髋关节的结构和功能已造成巨大破坏,治疗复杂,给患者造成了沉重的负担。中国人民解放军联勤保障部队第九四〇医院收治的1例以左髋关节疼痛为首发症状的年轻患者,初步考虑为左髋关节结核,经一期骨水泥旷置术及规律抗结核治疗5个月后感染复发,二次旷置并行基因检测后确诊为左髋关节广泛耐药性结核分枝杆菌感染。Extensively drug-resistant mycobacterium tuberculosis infection of the hip joint is rare in clinical practice,and its diagnosis requires a long median time.It is often at an advanced stage at the time of diagnosis.It has caused great damage to the structure and function of the hip joint,and its treatment is complicated,which causes a heavy burden on patients.A young patient with left hip joint pain as the first symptom was admitted to our hospital,initially he was considered having mycobacterium tuberculosis infection of the left hip joint.But the infection recurred after 5 mouths with a primary bone cement exclusion surgery and regular anti-tuberculosis treatment.So we had to perform the second surgery and genetic testing.Later,he was diagnosed as extensively drug-resistant mycobacterium tuberculosis infection in the left hip joint.

关 键 词：广泛耐药性结核分枝杆菌 髋关节二期翻修术 抗结核治疗 

分 类 号：R529.2[医药卫生—内科学]