北京市某医院接受抗梅毒治疗孕产妇发生妊娠不良结局情况分析  

Analysis of adverse pregnancy outcomes of pregnant women receiving anti-syphilis treatment in Beijing

作　　者：李秋云[1] 李建维[1] LI Qiuyun;LI Jianwei(Beijing You'an Hospital,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院,北京100069

出　　处：《中国艾滋病性病》2022年第4期468-471,共4页Chinese Journal of Aids & STD

基　　金：乙肝病毒携带产妇产后随访管理模式的开放和应用研究(2020-109)。

摘　　要：目的了解梅毒感染孕产妇接受抗梅毒治疗和发生妊娠不良结局的现况,探索影响妊娠不良结局的因素。方法通过对2016-2020年北京市某医院“预防艾滋病、梅毒和乙肝母婴传播管理信息系统”中接受治疗的孕产妇数据进行分析,包括人口学特征、分娩、接受治疗、妊娠结局等情况,利用χ^(2)检验和多因素Logistic回归分析接受治疗的梅毒孕产妇发生妊娠不良结局的影响因素。结果204例接受治疗的梅毒孕产妇平均年龄(31.0±4.9)岁,其中既往感染占89.2%(182例),90.2%(184例)接受了规范治疗,71.3%(139/195)治疗前梅毒滴度1∶4。9.3%(19例)发生了妊娠不良结局。多因素Logistic回归分析结果显示,梅毒感染初产妇发生妊娠不良结局的风险高于2次及以上分娩的孕产妇(OR=4.030,95%CI:1.436~11.306),未规范用药的梅毒感染孕产妇风险高于规范用药的孕产妇(OR=4.161,95%CI:1.229~14.084)。结论对于既往未规范治疗和初次分娩的梅毒感染孕产妇要重点关注,预防发生妊娠不良结局和梅毒母婴传播。Objective To understand the adverse pregnancy outcomes of pregnant women receiving anti-syphilis treatment and related factors.Methods Data come from Management Information System for Prevention of Mother-toChild Transmission of AIDS,Syphilis and Hepatitis B in a hospital in Beijing from 2016 to 2020,including demographic characteristics,delivery,treatment and pregnancy outcomes.χ^(2)test and multivariate Logistic regression were used to analyze the influencing factors of adverse pregnancy outcomes among the pregnant women receiving the anti-syphilis treatment.Results The average age of 204 syphilis pregnant women who received treatment was 31.0±4.9 years old.89.2%(182 cases)had been infected before and 90.2%(184 cases)received standardized treatment.71.3%(139/195cases)had a titer of 1:4 before the treatment.9.3%(19 cases)had adverse pregnancy outcomes.Multivariate Logistic regression analysis showed that the risk of adverse pregnancy was higher in syphilis infected women who gave birth for the first time than those who gave birth for two or more times(OR=4.030,95%CI:1.436-11.306).The risk was also higher in pregnant women without standardized treatment than that with standardized treatment(OR=4.161,95%CI:1.229-14.084).Conclusions Special attention should be paid to the syphilis-infected pregnant women who haven’t received standardized treatment before and who have given birth for the first time,in order to prevent adverse pregnancy outcomes and mother-to-child transmission of syphilis.

关 键 词：梅毒 孕产妇 不良结局 治疗 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]