同步放化疗治疗中晚期宫颈癌的疗效观察  

Effect of Concurrent Chemoradiotherapy in the Treatment of Advanced Cervical Cancer

作　　者：韩雪[1] HAN Xue(Department of Obstetrics and Gynecology,Tieling Central Hospital,Liaoning Tieling 112000)

机构地区：[1]铁岭市中心医院妇产科,辽宁铁岭112000

出　　处：《中国医疗器械信息》2022年第8期49-51,共3页China Medical Device Information

摘　　要：目的:探讨中晚期宫颈癌应用同步放化疗治疗的临床效果。方法:随机选取2018年8月~2020年2月于本院收治的60例中晚期宫颈癌患者进行临床疗效研究,其中对照组30例采用单纯放疗治疗(疾病类型:腺癌7例、鳞癌14例、腺鳞癌9例;临床分期:Ⅱb8例、Ⅲa14例、Ⅲb5例、IVa3例);观察组30例采用同步放化疗治疗(疾病类型:腺癌6例、鳞癌15例、腺鳞癌9例;临床分期:Ⅱb7例、Ⅲa14例、Ⅲb6例、IVa3例)。对比两组患者的临床疗效、不良反应、1年生存率、局部复发率、远处转移率。结果:采用同步放化疗的观察组治疗总有效率高达93.33%,显著优于对照组的56.67%;对照组肝功能损伤5例、胃肠道反应10例、放射性膀胱炎5例、骨髓抑制14例与观察组肝功能损伤5例、胃肠道反应9例、放射性膀胱炎6例、骨髓抑制13例差异不显著,P>0.05,无统计学意义;此外观察组1年生存差异对比显著,P<0.05,有统计学意义。两组患者,观察组1年生存率73.33%、局部复发率16.67%、远处转移率13.33%显著优于对照组1年生存率46.67%、局部复发率40.00%、远处转移率40.00%。结论:在中晚期宫颈癌治疗中,采用同步放化疗进行治疗能有效提升治疗效果,同时还能有效降低肿瘤病灶增殖分裂,降低复发率,提升患者生存时长。Objective:To investigate the clinical effect of concurrent chemoradiotherapy in the treatment of advanced cervical cancer.Methods:A total of 60 patients with advanced cervical cancer who were treated in our hospital from August 2018 to February 2020 were randomly selected for clinical efficacy study,of which 30 patients in the control group were treated with radiotherapy alone(disease type:7 cases of adenocarcinoma,14 cases of squamous cell carcinoma,9 cases of adenosquamous carcinoma;clinical stage:8 cases of Ⅱb,14 cases of Ⅲa,5 cases of Ⅲb,and 3 cases of Ⅳa);30 cases in the observation group were treated with concurrent chemoradiotherapy(disease type:6 cases of adenocarcinoma,15 cases of squamous cell carcinoma,9 cases of adenosquamous cell carcinoma;clinical stage:7 cases of Ⅱb,14 cases of Ⅲa,6 cases of Ⅲb,and 3 cases of Ⅳa).The clinical efficacy,adverse reactions,1-year survival rate,local recurrence rate,and distant metastasis rate were compared between the two groups.Results:The total effective rate of the observation group was 93.33%,which was significantly better than 56.67% of the control group;There were 5 cases of liver function injury,10 cases of gastrointestinal reaction,5 cases of radioactive cystitis and 14 cases of bone marrow suppression in the control group,which had no significant difference from 5 cases of liver function injury,9 cases of gastrointestinal reaction,6 cases of radioactive cystitis and 13 cases of bone marrow suppression in the observation group(P>0.05);In addition,there was significant difference in 1-year survival in the observation group(P<0.05).The 1-year survival rate,local recurrence rate and distant metastasis rate of the observation group were 73.33%,16.67% and 13.33%,which were significantly better than those of the control group,46.67%,40.00% and 40.00% respectively.Conclusion:In the treatment of middle and advanced cervical cancer,the use of concurrent chemoradiotherapy can effectively improve the therapeutic effect,and also effectively reduce the proli

关 键 词：放疗 化疗 同步放化疗 宫颈癌 中晚期 

分 类 号：R181.3[医药卫生—流行病学]