肝肠循环对霉酚酸药动学作用及其影响因素研究进展  

Research Progressi in the Influence of Enterohepatic Circulation on Pharmacokinetics of Mycophenolic Acid

作　　者：孙莎莎 陈冰[1] Sun Shasha;Chen Bing(Department of Pharmacy,Ruijin Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院药剂科,上海200025

出　　处：《中国药师》2022年第4期688-692,共5页China Pharmacist

基　　金：国家自然科学基金项目(编号:81973387)。

摘　　要：霉酚酸作为实体器官移植术后常规用药,在体内具有较显著的药动学和药效学差异,其中肝肠循环是差异来源的重要环节,其对霉酚酸体内暴露贡献约为40%,且个体差异较大。代谢酶、转运体基因多态性、食物、合并用药及疾病等可通过影响霉酚酸肝肠循环导致其体内暴露发生变化。本文主要就霉酚酸肝肠循环影响因素进行综述。As a routine drug of immunosuppressive therapy after organ transplantation,mycophenolic acid(MPA) performs large between-and within-subject pharmacokinetic and pharmacodynamic variability,of which enterohepatic circulation is an important factor,contributing to 40% of MPA in vivo exposure.Genetic polymorphism of metabolism enzyme and transporters,food,concomitant drug and diseases can influence enterohepatic circulation of MPA,and further impact the exposure.This article reviewed the factors influencing the enterohepatic circulation of mycophenolic acid.

关 键 词：霉酚酸 药动学 肝肠循环 基因多态性 药物相互作用 

分 类 号：R969.1[医药卫生—药理学]