红景天美白凝胶的制备及质量标准  

Preparation and Quality Standard of Rhodiola Whitening Gel

作　　者：于英杰 耿宏侠 吴亚男[1] 王宇佳 张新悦 严德康 郭睿博 李学涛[1] Yu Yingjie;Geng Hongxia;Wu Ya’nan;Wang Yujia;Zhang Xinyue;Yan Dekang;Guo Ruibo;Li Xuetao(School of Pharmacy,Liaoning University of Traditional Chinese Medicine,Liaoning Dalian 116600,China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《中国药师》2022年第4期720-723,共4页China Pharmacist

基　　金：“兴辽英才计划”项目(编号:XLYC1807132)。

摘　　要：目的:以大花红景天粗提物为原料,制备美白凝胶并考察其质量标准。方法:以感官评分为指标,采用Box-Behnken效应面法优选红景天美白凝胶处方;建立红景天苷的薄层色谱鉴别方法以及高效液相含量测定方法,考察红景天美白凝胶的质量标准。结果:Box-Behnken响应面法优化出美白凝胶的最优处方为卡波姆U21 1%、三乙醇胺0.375%、甘油12.5%、1,2-丙二醇2.5%、丁二醇5%;薄层色谱法鉴别到凝胶中含有红景天苷,高效液相法测定红景天苷平均含量为3.38 mg·g^(-1)结论:红景天美白凝胶处方可行,质量稳定可控,红景天苷含量测定的方法操作简单,快速准确,为后期的药效试验提供依据。Objective:To prepare whitening gel containing crude extract of Rhodiola crenulata as the raw material and to investigate its quality standard.Methods:The sensory score was used as the index,and Box-Behnken design-response surface method was used to optimize the formulation of Rhodiola whitening gel;thin-layer chromatography identification method and HPLC content determination method were established for salidroside to investigate the quality standard of the whitening gel.Results:The Box-Behnken design-response surface method optimized the formulation of whitening gel as follows:carbomer U21 1%,triethanolamine 0.375%,glycerol 12.5%,1,2-propanediol 2.5%,butanediol 5%;the TLC method identified salidroside in the gel,and the average content of salidroside determined by the HPLC method was 3.38 mg·g^(-1).Conclusion:The formulation of Rhodiola whitening gel is feasible,and the quality is stable and controllable.The method for the determination of salidroside is simple,fast and accurate,which provides basis for further study on the drug efficacy.

关 键 词：红景天 美白 处方优选 质量标准 

分 类 号：R283.6[医药卫生—中药学]