血小板/白蛋白和血小板/血红蛋白及C-反应蛋白/白蛋白各比值与糖尿病患病的相关性分析  

Correlation of platelet/albumin ratio,platelet/hemoglobin ratio and C-reactive protein/albumin ratio with diabetes in a population-based study

作　　者：徐阳[1] 韩拓 刘莉君[3] 王丽霞[2] 王怡雯 李盈[2] 张婷[2] 范雅洁 王聪霞[2] XU Yang;HAN Tuo;LIU Lijun;WANG Lixia;WANG Yiwen;LI Ying;ZHANG Ting;FAN Yajie;WANG Congxia(Department of Laboratory,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China;Department of Cardiology,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China;Department of Oncology,The Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第二附属医院检验科,陕西西安710004 [2]西安交通大学第二附属医院心血管内科,陕西西安710004 [3]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2022年第3期348-353,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81273878)。

摘　　要：目的探究血小板/白蛋白比值(platelet/albumin ratio,PAR)、血小板/血红蛋白比值(platelet/hemoglobin,PHR)及C-反应蛋白/白蛋白比值(C-reactive protein/albumin,CAR)与糖尿病患病之间的相关性。方法基于中国健康与营养调查CHNS2009数据,通过ID进行性别、年龄匹配,纳入具有血清学检测结果的8258例人群样本数据,以空腹血糖≥7.0 mmol/L或糖化血红蛋白(HbA1c)≥6.5%分为糖尿病组与对照组,比较组间的血脂与血细胞变化、PAR与PHR及CAR差异,并进行糖尿病患病相关性分析。结果糖尿病组中血尿酸、总胆固醇、三酰甘油及低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)较对照组显著升高,高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)则显著降低。其次,糖尿病组中PAR和PHR与对照组差异无统计学意义,而CAR则显著升高(0.48±0.18 vs.0.08±0.23,P<0.001),并与空腹血糖(r=0.1818,P<0.001)、HbA1c(r=0.1866,P<0.001)及胰岛素抵抗内稳态模型(HOMA-IR)(r=0.1881,P=0.003)均呈显著正相关,但CAR并非糖尿病的独立危险因素。此外,红细胞计数(B=1.324,95%CI:1.182~1.483,P<0.001)和白细胞计数(B=1.230,95%CI:1.166~1.298,P<0.001)升高可能是糖尿病患病的独立危险因素。结论CAR与糖尿病存在一定相关性,但并非其独立危险因素;血脂异常和白细胞、红细胞计数升高可能是糖尿病患病的独立危险因素。Objective To investigate the association of platelet/albumin ratio(PAR), platelet/hemoglobin(PHR)and C-reactive protein/albumin(CAR)with diabetes mellitus. Methods Based on the data of China Health and Nutrition Survey(CHNS2009), with gender and age matched by their ID, a total of 8 258 individuals with serological test results were finally included and were divided into diabetes group and control group according to the fasting blood glucose and HbA1c, and then the blood lipid and blood cell changes, PAR, PHR and CAR differences between groups were compared, and the correlation analysis of diabetes was performed. Results Compared with those in the control group,serum uric acid, total cholesterol, triacylglycerol and low-density lipoprotein cholesterol(LDL-C) were significantly increased in diabetes group, while high-density lipoprotein cholesterol(HDL-C)was significantly decreased. Besides,there was no significant difference in PAR or PHR between the two groups, while CAR was significantly increased in diabetes(0. 48±0. 18 vs. 0. 08±0. 23, P<0. 001), and was positively correlated with the levels of fasting glucose(r=0. 181 8, P<0. 001), HbA1c(r=0. 186 6, P<0. 001), and HOMA-IR(r=0. 188 1, P=0. 003). However,CAR was not an independent risk factor for diabetes. In addition, increased red blood cell count(B=1. 324,95% CI:1. 182-1. 483,P<0. 001)and leukocytes count(B=1. 230,95% CI:1. 166-1. 298, P<0. 001)may be independent risk factors for the incidence of diabetes. Conclusion CAR is correlated with diabetes mellitus, but it is not an independent risk factor. Dyslipidemia, elevated leukocytes and red blood cell counts may be independent risk factors for diabetes,but further study is needed.

关 键 词：糖尿病 血脂异常 血小板/白蛋白比值 血小板/血红蛋白比值 C-反应蛋白/白蛋白比值 

分 类 号：R446.1[医药卫生—诊断学]