乳腺癌患者QTc延长的发生率及其影响因素分析  

Prevalence of QTc prolongation in breast cancer patients and the risk factors

作　　者：钱华 谭茗月 李文远 李国良[2] 刘艳 QIAN Hua;TAN Mingyue;LI Wenyuan;LI Guoliang;LIU Yan(Electrocardiogram Room,Department of Cardiology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Cardiology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院心内科心电图室,陕西西安710061 [2]西安交通大学第一附属医院心内科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2022年第3期426-429,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省重点研发计划项目(No.2017ZDCXL-SF-02-04-01)。

摘　　要：目的 探讨乳腺癌患者住院期间QTc延长的发生率及其影响因素。方法 回顾性收集2018年1月-2018年12月西安交通大学第一附属医院收治的经病理诊断确诊的乳腺癌患者296例,分析其临床基线资料,根据患者12导联心电图检查结果,观察经心率校正的QTc的数值,取QTc max,采用多因素Logistic回归分析法探讨可能引起QTc延长的影响因素。结果 乳腺癌患者QTc延长的发生率为13%;多因素Logistic回归分析结果提示,心率(OR=1.04,P<0.05)、高血压(OR=6.48,P<0.05)、蒽环类药物(OR=3.96,P<0.05)是乳腺癌患者QTc间期延长的危险因素。结论 乳腺癌患者QTc延长的发生率增高;其中患者心率增快、合并高血压以及使用蒽环类药物是患者QTc间期延长的危险因素。Objective To investigate the prevalence of QTc prolongation and the risk factors in hospitalized breast cancer patients.Methods A total of 296 patients with pathologically diagnosed breast cancer admitted to The First Affiliated Hospital of Xi’an Jiaotong University in 2018 were retrospectively enrolled.The patients’baseline data,12-lead ECG,the prevalence of QTc(QTc max)prolongation and its risk factors were analyzed by the multivariate logistic regression.Results The prevalence of QTc prolongation in the hospitalized breast cancer patients was 13%;multivariate logistic regression analysis showed that increased heart rate(OR=1.04,P<0.05),combined hypertension(OR=6.48,P<0.05),and anthracycline administration(OR=3.96,P<0.05)were the risk factors of the prolongation of QTc interval in the breast cancer patients(P<0.05).Conclusion The prevalence of prolonged QTc interval in the hospitalized breast cancer patients is increased,which may be due to the increased heart rate,hypertension,and the administration of anthracycline drugs in these patients.

关 键 词：乳腺癌 QTC间期 蒽环类药物 影响因素 

分 类 号：R541.7[医药卫生—心血管疾病]