儿童紫癜性肾炎血清半胱氨酸蛋白酶抑制剂C和尿微量清蛋白与病理分级的相关性  

Correlation of serum Cysteine C and urine microalbumin with pathological grade in children with Henoch-Schonlein purpura nephritis

作　　者：郑燕 卢玉容 文海波 贺元平 申敏 徐娟 蔡强[1] ZHENG Yan;LU Yurong;WEN Haibo;HE Yuanping;SHEN Min;XU Juan;CAI Qiang(Department of Pediatrics,The Second People's Hospital of Yibin,Yibin 644000,Sichuan,China)

机构地区：[1]宜宾市第二人民医院儿科,四川宜宾644000

出　　处：《西部医学》2022年第5期744-747,共4页Medical Journal of West China

基　　金：四川省卫生和计划生育委员会科研课题(150253)。

摘　　要：目的探讨儿童紫癜性肾炎血清半胱氨酸蛋白酶抑制剂C(Cyst-C)和尿微量清蛋白(mA1b)与病理分级的相关性。方法选取2018年2月~2021年2月我院收治的紫癜性肾炎(HSPN)患儿112例作为研究对象,根据肾脏病理分级分为≤Ⅱa级组28例、Ⅱb级组31例、Ⅲa级组30例、≥Ⅲb级组23例,采取酶联免疫吸附法(ELISA)检测各组Cyst-C水平,免疫比浊法检测mA1b水平,采用Spearman相关性分析评价Cyst-C和mA1b与肾脏病理分级的关系。结果血清Cyst-C和尿mA1b水平在各肾脏病理分级患儿中比较差异均具统计学意义(P<0.05),随病理分级严重程度增高而上升(P<0.05);Cyst-C和mA1b与肾脏病理分级之间均呈正相关(r_(1)=0.969,r_(2)=0.981)。结论随着HSPN患儿肾脏病理分级升高,血Cyst-C和尿mA1b水平也不断升高,它们在一定程度上均可反映肾脏损伤严重程度。Objective To investigate the correlation of serum Cystatin C(Cyst-C)and urine microalbumin(mA1b)with pathological grade in children with Henoch-Schonlein purpura nephritis(HSPN).Methods 112 children with HSPN admitted to the hospital were selected as the research subjects between February 2018 and February 2021.According to renal pathological classification,the children were divided into≤Ⅱa group(28 cases),Ⅱb group(31 cases),Ⅲa group(30 cases),and≥Ⅲb group(23 cases).Enzyme-linked immunosorbent assay(ELISA)was used to detect the Cyst-C level,and immunoturbidimetry was used to detect the mA1b level.Spearman correlation analysis was performed to evaluate the relationship of Cyst-C and mA1b with renal pathological grade.Results Serum Cyst-C and urine mA1b levels showed statistically significant differences between children with different renal pathological grades(P<0.05),and increased with the increase of pathological grades(P<0.05).Cyst-C and mA1b were positively correlated with renal pathological grade(r_(1)=0.969,r_(2)=0.981).Conclusion With the increase of renal pathological grade in HSPN children,the levels of blood cyst-c and urinary mca1b also increased,which can reflect the severity of renal injury to some extent.

关 键 词：紫癜性肾炎 儿童 半胱氨酸蛋白酶抑制剂C 尿微量清蛋白 

分 类 号：R692.34[医药卫生—泌尿科学]