1型糖尿病精准医学的新征程  

A journey towards precision medicine in type 1 diabetes mellitus

作　　者：周智广[1] Zhou Zhiguang(Department of Metabolism and Endocrinology,the Second Xiangya Hospital,Central South University,Key Laboratory of Diabetes Immunology(Central South University),Ministry of Education,National Clinical Research Center for Metabolic Diseases,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院代谢内分泌科,糖尿病免疫学教育部重点实验室,国家代谢性疾病临床医学研究中心,长沙410011

出　　处：《中华医学杂志》2022年第16期1129-1132,共4页National Medical Journal of China

基　　金：国家重点研发计划(2016YFC1305000,2016YFE0107500,2018YFE0114500);国家科技支撑计划(2015BAI12B13);国家自然科学基金(81820108007);湖南省科技创新计划(2020RC4044)。

摘　　要：糖尿病是一组病因病理与临床特征高度异质性的疾病。1型糖尿病(T1DM)在遗传学、免疫学、代谢学及治疗学等方面呈现不同的内在型与临床表型。精准医学的兴起为糖尿病的深入研究及临床防控提供了新思路和新策略。本文将阐述T1DM精准医学在诊断、预防、治疗、预测及监测方面的基本概念、研究进展与可能的发展方向。Diabetes is a group of highly heterogenous diseases with multiple etiopathologies and clinical characteristics.In type 1 diabetes mellitus,there are different endotypes and clinical phenotypes based on genetics,immunology,metabolism and therapeutics.Precision medicine provides novel ideas and strategies for further studies and clinical prevention/control of diabetes.The article summarizes the concepts,progress and future directions of precision medicine for the diagnosis,prevention,treatment,prognosis,and monitoring of diabetes.

关 键 词：糖尿病 1型 精准医学 异质性 自身免疫 

分 类 号：R587.1[医药卫生—内分泌]