磁共振引导聚焦超声术治疗难治性子宫腺肌病的疗效评估  

Efficacy of magnetic resonance guided focused ultrasound surgery in the treatment of refractory adenomyosis

作　　者：王娟 周守国 黄耀渠 WANG Juan;ZHOU Shou-guo;HUANG Yao-qu(Department of MR,Foshan Hospital of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Guangdong 528000,China)

机构地区：[1]广州中医药大学附属佛山中医院MR室,广东528000

出　　处：《放射学实践》2022年第5期584-588,共5页Radiologic Practice

基　　金：佛山市科技攻关资助项目(2018AB000561);广东省中医药局科研资助项目(20212219)。

摘　　要：目的:探讨磁共振引导聚焦超声术(MRgFUS)治疗难治性子宫腺肌病的临床疗效。方法:以本院行MRgFUS治疗的38例难治性子宫腺肌病患者为研究对象,比较患者治疗前、治疗后3个月及治疗后6个月的病灶体积、疼痛评分、月经量月经失血图(PBAC)评分、CA125、血红蛋白及不良反应方面的情况。采用方差分析比较治疗前后相关参数的差异,采用Pearson法进行数据相关性分析。结果:患者MRgFUS治疗前、治疗后3个月及治疗后6个月的病灶体积、VAS评分、月经量PBAC评分、CA125、血红蛋白值的差异具有统计学意义(F值分别为51.628、390.167、278.155、138.817、29.092,P值均<0.05)。病灶体积与VAS评分、月经量PBAC评分、CA125、血红蛋白存在相关性,相关系数分别为0.705、0.715、0.578、-0.439(P值均<0.05)。结论:MRgFUS作为一种新型无创的治疗难治性子宫腺肌病的方法,能对病灶进行有效治疗,改善症状,值得临床推广应用。Objective:To investigate the clinical effects of magnetice resonance guided focused ultrasound surgery(MRgFUS)in the treatment of refractory adenomyosis.Methods:38 patients with refractory adenomyosis admitted to our hospital were treated with MRgFUS.The lesion volume,pain VAS score,menstrual volume PBAC score,CA125,hemoglobin and adverse reactions were compared before treatment,3 and 6 months after treatment.ANOVA(analysis of variance)was used to compare the differences of related parameters before and after treatment,and Pearson method was used for data correlation analysis.Results:There were statistically significant differences in lesion volume,pain VAS score,menstrual volume PBAC score,CA125 and hemoglobin among before treatment,3 and 6 months after MRgFUS treatment(F value was 51.628,390.167,278.155,138.817 and 29.092,respectively,all P<0.05).Lesion volume was correlated with pain VAS score,menstrual volume PBAC score,CA125 and hemoglobin,with correlation coefficients of 0.705,0.715,0.578 and-0.439,respectively(all P<0.05).Conclusion:MRgFUS,as a new non-invasive method for the treatment of refractory adenomyosis,can effectively treat the lesions and improve the symptoms,which is worthy of clinical application.

关 键 词：磁共振成像 磁共振引导聚焦超声术 子宫腺肌病 疗效 

分 类 号：R713.4[医药卫生—妇产科学] R445.2[医药卫生—临床医学]